Genetic variants and interactions from a pharmacist-led pharmacogenomics service for PACE

Pharmacogenomics
Kevin T BainDavid McGain

Abstract

Aim: Evaluate results of pharmacogenomics testing for participants enrolled in the Program of All-inclusive Care for the Elderly (PACE). Materials & methods: A convenience sample of 100 participants from the PHARM-GENOME-PACE study. Genetic variants were determined by pharmacogenomics testing. Drug-gene interactions (DGIs), drug-drug-gene interactions (DDGIs) and phenoconversions were interrogated from a clinical decision support system. Results: In total, 146 genetic variants, 169 DGIs and 125 DDGIs were detected. DGIs and DDGIs occurred most commonly with the CYP2D6 gene (36.1 and 39.2%, respectively). There were 280 instances of phenoconversions; majority (62.9%) affecting the CYP3A4 isoenzyme. Conclusion: Prevalence of exposures to DGIs and DDGIs among PACE participants is high. Pharmacists using a clinical decision support system can support PACE practitioners with assessing multidrug simultaneous interactions. Clinical trial registration: NCT03257605.

References

Nov 1, 1993·Clinical Pharmacology and Therapeutics·S V OttonE M Sellers
Nov 17, 2001·JAMA : the Journal of the American Medical Association·K A PhillipsW Sadee
Apr 4, 2003·JAMA : the Journal of the American Medical Association·David N JuurlinkDonald A Redelmeier
May 27, 2005·The New England Journal of Medicine·Grant R Wilkinson
Aug 13, 2008·Analytical and Bioanalytical Chemistry·Ulrich M ZangerMatthias Schwab
Nov 12, 2009·Clinical Pharmacokinetics·Shu-Feng Zhou
Jul 6, 2010·Ageing Research Reviews·Davide SeripaAlberto Pilotto
Dec 7, 2010·Journal of the American Medical Informatics Association : JAMIA·Kim R SavernoDaniel C Malone
Mar 18, 2011·Clinical Pharmacology and Therapeutics·J J SwenH-J Guchelaar
May 6, 2011·Expert Opinion on Drug Safety·Pamela L SmithburgerSandra L Kane-Gill
Oct 25, 2011·The American Journal of Geriatric Pharmacotherapy·Hubert Zakrzewski-JakubiakCara Tannenbaum
Oct 26, 2011·Expert Opinion on Drug Safety·Lara MagroRoberto Leone
Nov 15, 2011·The American Journal of Geriatric Pharmacotherapy·Lisa E Hines, John E Murphy
Jan 11, 2012·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Carla Bouwmeester
May 15, 2012·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Paulo Roque Obreli NetoRoberto Kenji Nakamura Cuman
Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Maurizio CardelliMauro Provinciali
Apr 2, 2013·The Journal of Clinical Psychiatry·Sheldon H PreskornChristine J Guico-Pabia
Jan 25, 2014·Clinical Pharmacology and Therapeutics·K R CrewsUNKNOWN Clinical Pharmacogenetics Implementation Consortium
Apr 22, 2014·Expert Review of Clinical Pharmacology·Cara Tannenbaum, Nancy L Sheehan
Aug 27, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Andrew A MonteVasilis Vasiliou
May 15, 2015·Clinical Pharmacology and Therapeutics·J K HicksUNKNOWN Clinical Pharmacogenetics Implementation Consortium
Jan 2, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Brian Thomas HocumKristine Ashcraft
Apr 1, 2018·Journal of the American Pharmacists Association : JAPhA·Kevin T BainJacques Turgeon
Mar 31, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Emily J CicaliJulie A Johnson

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Citations

Feb 27, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·David L BankesKevin T Bain
Jul 9, 2020·Pharmacogenomics·Christina MitropoulouGeorge P Patrinos
Sep 4, 2021·Research in Social & Administrative Pharmacy : RSAP·Meagan HayashiSherif Hanafy Mahmoud
Oct 3, 2021·Human Genetics·Evangelia Eirini TsermpiniGeorge P Patrinos

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Methods Mentioned

BETA
pharmacotherapy

Clinical Trials Mentioned

NCT03257605

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