Genetic variants associated with insulin resistance and metabolic syndrome in young Asian Indians with myocardial infarction

Metabolic Syndrome and Related Disorders
Naresh RanjithLee Rom

Abstract

The objective of this study was to assess whether an association exists between the metabolic syndrome and polymorphisms in genes involved in insulin resistance in young Asian Indian patients presenting with acute myocardial infarction (AMI). The study population comprised 467 patients who were 45 years or younger. The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF) definitions were used to assess the prevalence of metabolic syndrome. We examined the genotype and allele frequencies of the IRS-I G972R, PPAR-gamma P12A, KCNJ11 E23K, and TNF-alpha -308G/A polymorphisms in relation to the metabolic syndrome determined by both definitions. The metabolic syndrome as defined by the NCEP ATP III criteria was found in 282 (60.4%) patients, and in 278 (59.5%) patients according to the IDF criteria. This gave only a moderate level of agreement of 79% between the two definitions (Cohen's kappa = 0.554). No association was found between the IRS-I G972R, PPAR-gamma P12A, and KCNJ11 E23K, or TNF-alpha -308G/A polymorphic variants and the metabolic syndrome, or its components, for either definition. Although the metabolic syndrome is a common finding in young Asian...Continue Reading

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P M HollandD H Gelfand
Apr 25, 2000·Biochemical and Biophysical Research Communications·K HaraT Kadowaki
Oct 4, 2000·Nature Genetics·D AltshulerL Kruglyak
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Nicola AbateScott M Grundy

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Citations

Nov 11, 2009·Metabolic Syndrome and Related Disorders·Jihène RejebAli Bouslama
Nov 11, 2009·Metabolic Syndrome and Related Disorders·Anoop Misra, Lokesh Khurana
May 25, 2010·Journal of Gastroenterology and Hepatology·Yong-Jian ZhouHong-Li Huang
Dec 14, 2012·World Journal of Gastroenterology : WJG·Yu-Yuan Li
Jan 26, 2012·Indian Journal of Endocrinology and Metabolism·Kaushik PanditSubhankar Chowdhury
Jul 14, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C M PovelE J M Feskens
Jul 24, 2012·The Tohoku Journal of Experimental Medicine·Chuang-Yu CaoYu-Jui Yvonne Wan
Jun 29, 2021·Journal of Diabetes and Metabolic Disorders·Dalia GhareebAmira S Al-Karamany

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