PMID: 26770579Jan 16, 2016Paper

Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population

International Journal of Clinical and Experimental Medicine
Xiaobin JiaTianbo Jin

Abstract

A number of recently published genome-wide association studies (GWAS) identified several genetic loci at 6p21, 10q23, 16q12 and 22q12 that were associated with digestive tract tumors, including esophageal cancer (EC). We conducted a case-control study in a Chinese Han population including 360 EC cases and 310 controls to evaluate whether these variants are related to EC susceptibility. All these SNPs were genotyped using Sequenom Mass-ARRAY technology. For each SNP, genotypic frequencies in controls were tested for departure from Hardy-Weinberg Equilibrium (HWE) using an exact test. A P-value of 0.05 was considered the threshold for statistical significance. We compared the allele frequencies of cases and controls using the chi-squared (χ(2)) test. Associations between the gene and the risk of esophagus cancer were tested using various genetic models (co-dominant, dominant, recessive, and log-additive) and analysis by SNP stats. Odds ratios and 95% confidence intervals (CIs) were calculated by unconditional logistic regression with adjustments for age and gender. We found significant association with risk of EC for five reported SNPs, including rs2274223 in PLCE1 at 10q23 [odds ratio (OR) = 1.390; 95% confidence interval (CI) =...Continue Reading

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