Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review

Journal of Clinical Medicine
Kwang Seob LeeJae Il Shin

Abstract

A number of genome-wide association studies (GWASs) and meta-analyses of genetic variants have been performed in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We reinterpreted previous studies using false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP). This study searched publications in PubMed and Excerpta Medica Database (EMBASE) up to February 2018. Identification of noteworthy associations were analyzed using FPRP and BFDP, and data (i.e., odds ratio (OR), 95% confidence interval (CI), p-value) related to significant associations were separately extracted. Using filtered gene variants, gene ontology (GO) enrichment analysis and protein⁻protein interaction (PPI) networks were performed. Overall, 241 articles were identified, and 7 were selected for analysis. Single nucleotide polymorphisms (SNPs) discovered by GWASs were shown to be noteworthy, whereas only 27% of significant results from meta-analyses of observational studies were noteworthy. Eighty-five percent of SNPs with borderline p-values (5.0 × 10-8 < p < 0.05) in GWASs were found to be noteworthy. No overlapping SNPs were found between PR3-ANCA and MPO-ANCA vasculitis. GO analysis revealed immune-related GO ter...Continue Reading

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Citations

Oct 11, 2019·Current Opinion in Rheumatology·Patrick BolandSabina Sandigursky
Jan 11, 2020·Frontiers in Immunology·Erkan DemirkayaIvona Aksentijevich
Jul 20, 2020·The Pharmacogenomics Journal·Arno C HesselsCoen A Stegeman
Oct 8, 2020·International Journal of Molecular Sciences·Andreas KronbichlerJae Il Shin
Jan 26, 2021·Computational and Structural Biotechnology Journal·Andreas KronbichlerJosef Wagner
Apr 17, 2021·Scientific Reports·Isabella BattenNollaig M Bourke

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