Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.

Cancer Causes & Control : CCC
Temitope O KekuRobert Millikan

Abstract

Evaluating genetic susceptibility may clarify effects of known environmental factors and also identify individuals at high risk. We evaluated the association of four insulin-related pathway gene polymorphisms in insulin-like growth factor-1 (IGF-I) (CA)( n ) repeat, insulin-like growth factor-2 (IGF-II) (rs680), insulin-like growth factor-binding protein-3 (IGFBP-3) (rs2854744), and adiponectin (APM1 rs1501299) with colon cancer risk, as well as relationships with circulating IGF-I, IGF-II, IGFBP-3, and C-peptide in a population-based study. Participants were African Americans (231 cases and 306 controls) and Whites (297 cases, 530 controls). Consenting subjects provided blood specimens and lifestyle/diet information. Genotyping for all genes except IGF-I was performed by the 5'-exonuclease (Taqman) assay. The IGF-I (CA)(n) repeat was assayed by PCR and fragment analysis. Circulating proteins were measured by enzyme immunoassays. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated by logistic regression. The IGF-I (CA)( 19 ) repeat was higher in White controls (50 %) than African American controls (31 %). Whites homozygous for the IGF-I (CA)(19) repeat had a nearly twofold increase in risk of colon cancer (OR ...Continue Reading

References

Jan 1, 1991·The American Journal of Clinical Nutrition·G Block
Sep 1, 1986·American Journal of Epidemiology·G BlockL Gardner
Mar 1, 1995·Cancer Causes & Control : CCC·E Giovannucci
Feb 1, 1994·The Journal of Clinical Endocrinology and Metabolism·P C KaoC A Lang
Jul 2, 1997·Journal of the National Cancer Institute·M E MartínezG A Colditz
May 5, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R WinklerD Hodzic
Jul 7, 1999·Journal of the National Cancer Institute·R E SchoenP J Savage
Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·O ManousosC Mantzoros
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·I TakacsM J Econs
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·E GiovannucciS E Hankinson
Aug 2, 2001·Nature Medicine·A H BergP E Scherer
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Stacey A MissmerSusan E Hankinson
Feb 20, 2003·European Journal of Endocrinology·Ingrid RietveldSteven W J Lamberts
Mar 1, 2003·British Journal of Cancer·K DeLellisN M Probst-Hensch
May 6, 2003·Current Diabetes Reports·Francis VasseurPhilippe Froguel
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Richard PalmqvistRudolf Kaaks
Aug 26, 2003·American Journal of Epidemiology·Abraham M Y NomuraMichael N Pollak
Dec 16, 2003·European Journal of Human Genetics : EJHG·Emanuela FilippiMarco Giorgio Baroni
Apr 8, 2004·Journal of the National Cancer Institute·Jing MaMeir J Stampfer
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mercedes Gil-CamposAngel Gil
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryWade Samowitz
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joellen M SchildkrautPhilip J Walther
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Libby M MorimotoJohn D Potter
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Loïc Le MarchandLynne R Wilkens
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ronghua ZhaoMarcia Cruz-Correa
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Temitope O KekuRobert S Sandler
Nov 17, 2005·Journal of the National Cancer Institute·Esther K WeiChristos S Mantzoros

❮ Previous
Next ❯

Citations

Dec 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hui-Jie FanYan-Ru Qin
Aug 21, 2013·Postgraduate Medical Journal·Marc BardouMyriam Martel
Jul 23, 2013·International Journal of Medical Sciences·Chuncui YePeng Sun
Apr 12, 2014·Genetic Testing and Molecular Biomarkers·Qiaoxin LiWei Zhang
Aug 22, 2013·Cancer Epidemiology·Leon RaskinStephen B Gruber
Sep 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei ZhaoMeng-Zhong Liu
Oct 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuan PeiWenquan Niu
Oct 19, 2016·International Journal of Cancer. Journal International Du Cancer·Colinda C J M SimonsMatty P Weijenberg
Apr 25, 2019·International Journal of Cancer. Journal International Du Cancer·Sander de KortMatty P Weijenberg
Jan 16, 2019·BioMed Research International·Pedro Leopoldo Silva DoriaSergio Haimovich
Nov 7, 2013·Cancer Causes & Control : CCC·Heather M Ochs-BalcomLi Li
Apr 12, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xuan TanLin Ye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Anthony S RobbinsAhmedin Jemal
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Brooke E SylvesterOlufunmilayo I Olopade
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Krishan KumarHassan Ashktorab
International Journal of Cancer. Journal International Du Cancer
Hassan AshktorabFrancis Giardiello
© 2021 Meta ULC. All rights reserved