Genetic variants in lncRNA H19 are associated with the risk of oral squamous cell carcinoma in a Chinese population

Oncotarget
Zhiyao YuanHua Yuan

Abstract

To evaluate whether the genetic variants in H19 influence the risk of oral squamous cell carcinoma (OSCC) in a Chinese population, a case-control study was conducted to analyze four functional single nucleotide polymorphisms (SNPs) in H19. The cohort comprised of 444 OSCC cases and 984 healthy controls, and the study further evaluated the biological effect by bioinformatics prediction and functional experiments. Two SNPs, rs217727 and rs2839701, were found to be associated with the risk of OSCC [rs217727: odds ratio (OR) = 1.32, 95% confidence interval (CI) = 1.11-1.58, P = 0.002; rs2839701: OR = 1.23, 95% CI = 1.04-1.46, P = 0.019].Bioinformatics predicted that rs2839701 C>G might alter the secondary structure of H19. In addition, rs2839701 C>G inhibited the transcription activity and was correlated with the decreased expression of downstream gene MRPL23-AS1 that was downregulated in OSCC. The current results suggested that the SNPs in H19 may play a major role in genetic susceptibility to OSCC.

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Citations

Dec 20, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xu LiuJian Zhang
Nov 30, 2018·Journal of Clinical Laboratory Analysis·Safa Abdollahzadeh, Saeid Ghorbian
Nov 27, 2020·International Journal of Molecular Sciences·Guomin HuangHong Zhang
Nov 26, 2020·Journal of Cellular and Molecular Medicine·Tianbao TanTianyou Yang
Dec 4, 2020·Oral Diseases·Wu ZhouBing-Mu Fang
Dec 29, 2020·Pathology, Research and Practice·Esmat AbdiReza Safaralizadeh
Dec 19, 2020·Scientific Reports·Tamina Elias-RizkGeorge Hilal
Jun 3, 2021·International Journal of Molecular Sciences·Cing-Syuan LeiJing-Wen Shih

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Methods Mentioned

BETA
Genotyping
Assay
reverse transcription PCR
PCR

Software Mentioned

Stata
RNAfold
Haploview
SNPinfo

Related Concepts

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