Genetic variants in SEC16B are associated with body composition in black South Africans

Nutrition & Diabetes
Venesa SahibdeenZané Lombard

Abstract

The latest genome-wide association studies of obesity-related traits have identified several genetic loci contributing to body composition (BC). These findings have not been robustly replicated in African populations, therefore, this study aimed to assess whether European BC-associated gene loci played a similar role in a South African black population. A replication and fine-mapping study was performed in participants from the Birth to Twenty cohort (N = 1,926) using the Metabochip. Measurements included body mass index (BMI), waist and hip circumference, waist-to-hip ratio (WHR), total fat mass, total lean mass and percentage fat mass (PFM). SNPs in several gene loci, including SEC16B (Padj <  9.48 × 10-7), NEGR1 (Padj < 1.64 × 10-6), FTO (Padj < 2.91 × 10-5), TMEM18 (Padj < 2.27 × 10-5), and WARS2 (Padj < 3.25 × 10-5) were similarly associated (albeit not at array-wide signficance (P ≤ 6.7 × 10-7) with various phenotypes including fat mass, PFM, WHR linked to BC in this African cohort, however the associations were driven by different sentinel SNPs. More importantly, DXA-derived BC measures revealed stronger genetic associations than simple anthropometric measures. Association signals generated in this study were shared by E...Continue Reading

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Dec 21, 2018·Nursing Research·Theresa M HardyJacquelyn Y Taylor
Sep 15, 2019·Current Diabetes Reports·Ayo P DoumateyCharles N Rotimi
Aug 21, 2020·Molecular and Cellular Biochemistry·Kentaro Oh-HashiYoko Hirata
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Jan 10, 2021·International Journal of Molecular Sciences·Maria Nicol ArroyoMariana Igoillo-Esteve
Feb 28, 2021·EBioMedicine·Tinashe ChikoworeSegun Fatumo

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Methods Mentioned

BETA
X-ray
genotyping
PCA

Software Mentioned

ENCODE Encyclopaedia
GIANT
Evoker
R
EIGENSTRAT
Genesis
Quanto
Metabochip
GCTA
qqman

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