Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population

Reproductive Sciences
Jian RuanXue-Jun Zhang

Abstract

This study aimed to analyze the distribution of single-nucleotide polymorphisms (SNPs) of testis-expressed 15 (TEX15) gene in the Chinese Han infertile men and fertile men. This case-control study comprised 309 infertile men with nonobstructive azoospermia (NOA, n = 199) or severe oligozoospermia (SO, n = 110) and 377 fertile controls. Six SNPs were genotyped by Sequenom iplex technology. The results showed that the variants rs323346 and rs323347 contributed to the increasing risk of SO (P = .041, odds ratio [OR] = 1.635, 95% confidence interval [CI] = 1.018-2.628 and P = .046, OR = 1.616, 95% CI = 1.006-2.597). The haplotype AT of the SNPs rs323347 and rs323346 could reduce risk in the patients with SO (P = .040, OR = 0.616, and 95% CI = 0.383-0.990). The haplotype GC of the variants rs323347 and rs323346 conferred a significantly increased risk of SO (P = .040, OR = 1.624, 95% CI = 1.010-2.610). Thus, the polymorphisms rs323346 and rs323347 of the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.

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Citations

May 8, 2014·Journal of Assisted Reproduction and Genetics·Bing SongYun-xia Cao
Nov 12, 2015·The Journal of Obstetrics and Gynaecology Research·Makoto ChiharaTakayuki Enomoto
Jul 23, 2015·Human Molecular Genetics·Ozlem OkutmanStéphane Viville
Jul 29, 2020·Nature Communications·Theresa SchöppDónal O'Carroll
Apr 27, 2019·Basic and Clinical Andrology·Farah GhiehFrançois Vialard
Apr 4, 2021·International Journal of Molecular Sciences·Francesca CioppiCsilla Krausz
Apr 23, 2021·Basic and Clinical Andrology·Hela BellilFrançois Vialard
Jul 8, 2021·Electrophoresis·Huan TianWeibo Liang

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Methods Mentioned

BETA
genotyping
Assay
PCR

Software Mentioned

MassARRAY Typer
SHEsis
PS
MassARRAY Assay Design

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