Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia

Blood
Dong Hwan Dennis KimJeffrey H Lipton

Abstract

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder, characterized by the presence of BCR/ABL fusion gene. It is unclear which cellular events drive BCR/ABL gene translocation or initiate leukemogenesis in CML. Bcl-2 promotes survival of hematopoietic stem cells. Accordingly, apoptosis-related pathway may involve in the leukemogenesis of CML. In the current study, we evaluated 80 single nucleotide polymorphism (SNP) markers involved in the pathways of apoptosis (n = 30), angiogenesis (n = 7), myeloid cell growth (n = 14), xenobiotic metabolism (n = 13), WT1 signaling (n = 7), interferon signaling (n = 4), and others (n = 5) in 170 CML patients and 182 healthy controls. In a single-marker analysis, the following SNPs were identified including VEGFA, BCL2, CASP7, JAK3, CSF3, and HOCT1. In the multivariate logistic model with these SNPs and covariates, only BCL2 (rs1801018) was significantly associated with the susceptibility to CML (P = .05; odds ratio [OR] 2.16 [1.00-4.68]). In haplotype analyses, haplotype block of BCL2 consistently showed significant association with the susceptibility to CML. Risk allele analysis showed that a greater number of risk alleles from BCL2 SNP correlated to increasing risk of CML...Continue Reading

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Citations

May 28, 2010·Journal of Neurotrauma·Nicole Zangrilli HohYvette P Conley
Jul 2, 2010·The Journal of Clinical Investigation·Danilo PerrottiTomasz Skorski
Feb 8, 2014·PloS One·Christofer DiakosJoseph L Wiemels
Dec 18, 2013·Medical Oncology·Mervat Mamdooh KhorshiedRania Elsayed Sheir
Mar 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Syeda Kiran RiazMuhammad Faraz Arshad Malik
Sep 8, 2015·Leukemia Research·Vicent GuillemJuan Carlos Hernández-Boluda
Jun 11, 2016·Blood Cells, Molecules & Diseases·Natalia WeichAriela Fundia
Oct 17, 2015·Oncotarget·Heriberto Bruzzoni-GiovanelliPhilippe Rousselot
Apr 19, 2017·Journal of Cancer Research and Clinical Oncology·Jochen HessHagen Sjard Bachmann
Sep 21, 2012·Oncology Reports·Guanhua SongGuosheng Jiang

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