Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population

Genetics and Molecular Biology
Ana Carolina Proença da FonsecaPedro Hernán Cabello

Abstract

Obesity is a major public health problem worldwide. It has a complex etiology, influenced by environmental and genetic factors. FTO has been recognized as an important genetic factor for obesity development. This study evaluated the contribution of FTO polymorphisms (rs9939609 and rs17817449) for extreme obesity in terms of the period of obesity onset, anthropometric, and biochemical parameters. The haplotype and the combined effects of FTO risk alleles on obesity susceptibility were evaluated. We investigated 169 normal-weight subjects (body mass index, BMI: 22.8 [21.0; 24.0] kg/m2) and 123 extremely obese individuals (BMI: 47.6 [44.1; 53.1] kg/m2). Genotyping was performed by real time PCR. Our results showed a strong association between FTO variants and extreme obesity. Carriers of the AT haplotype had an increased risk for extreme obesity. Gene scores suggested that the risk of developing extreme obesity was increased 1.37-fold per risk allele added. Both polymorphisms also influenced BMI and body weight. Additionally, rs17817449 influenced triglyceride levels. No effect of FTO variants on the period of obesity onset was found. In conclusion, the FTO polymorphisms showed a strong association with development of extreme phen...Continue Reading

References

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Citations

Aug 5, 2020·International Journal of Food Sciences and Nutrition·Kubra Isgin-AticiZehra Buyuktuncer
Aug 27, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Darina FalbováRadoslav Beňuš

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Methods Mentioned

BETA
PCR
Genotyping
Assay

Software Mentioned

Haploview
SPSS
PHASE

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