Genetic Variants in WNT2B and BTRC Predict Melanoma Survival

The Journal of Investigative Dermatology
Qiong ShiQing-Yi Wei

Abstract

Cutaneous melanoma (CM) is the most lethal skin cancer. The Wnt pathway has an impact on development, invasion, and metastasis of CM, thus likely affecting CM prognosis. Using data from a published genome-wide association study from The University of Texas MD Anderson Cancer Center, we assessed the associations of 19,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autosomal genes with CM-specific survival and then validated significant SNPs in another genome-wide association study from Harvard University. In the single-locus analysis, 1,855 SNPs were significantly associated with CM-specific survival at P < 0.05, of which 547 SNPs were still considered noteworthy after the correction by the false-positive report probability. In the replication, two SNPs remained significantly associated with CM-specific survival after multiple comparison correction. By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 × 10-5) and 0.61 (0.46-0.80, 3.12×1...Continue Reading

References

Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·A de La CosteC Perret
Dec 11, 2002·The Journal of Cell Biology·Lisette HariLukas Sommer
Dec 21, 2002·International Journal of Cancer. Journal International Du Cancer·Eric KielhornDavid L Rimm
Apr 23, 2003·The American Journal of Pathology·Marco ChilosiClaudio Doglioni
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingeborg M BachmannLars A Akslen
Jul 11, 2008·The Journal of Investigative Dermatology·Mark P PurdueMargaret A Tucker
Jan 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andy J ChienRandall T Moon
Feb 14, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S Schinner
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Dec 19, 2009·BMC Proceedings·Joanna M BiernackaBrooke L Fridley
Nov 9, 2010·Genetic Epidemiology·Yun LiGonçalo R Abecasis
May 25, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ming YangPhilip W Kantoff
Sep 20, 2011·Human Molecular Genetics·Christopher I AmosQingyi Wei
Nov 2, 2011·Journal of the American Academy of Dermatology·Ahmedin JemalPhyllis A Wingo
Dec 17, 2011·Cancer Cell·William E DamskyMarcus Bosenberg
Jan 11, 2012·DNA Repair·Fengju SongJiali Han
Jan 28, 2012·CA: a Cancer Journal for Clinicians·Edgar P SimardAhmedin Jemal
May 29, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hongyan WangXiaoyuan Huang
Jun 12, 2012·Cell·Hans Clevers, Roel Nusse
Sep 20, 2012·Biochemical Society Transactions·Daniel C Berwick, Kirsten Harvey
Oct 20, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qiong-Zhu DongLun-Xiu Qin
Nov 7, 2012·Nature·UNKNOWN 1000 Genomes Project ConsortiumGil A McVean
Nov 20, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Nibaldo C InestrosaMarco Fuenzalida
Feb 15, 2013·The Journal of Investigative Dermatology·Chunying LiQingyi Wei
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Jul 13, 2013·Trends in Genetics : TIG·Eva Gómez-OrteJuan Cabello
Sep 17, 2013·Nature·Tuuli LappalainenEmmanouil T Dermitzakis
Oct 11, 2014·International Journal of Cancer. Journal International Du Cancer·Maider Ibarrola-VillavaNadem Soufir
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Jul 25, 2019·Molecular Carcinogenesis·Kirthana PrabhakarVijayasaradhi Setaluri
Jan 15, 2021·Nature Communications·Chia-Lung WuFarshid Guilak
May 20, 2021·Journal of Cardiovascular Pharmacology·Haozheng YuanXinsheng Han

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Hongyu LiQing-Yi Wei
International Journal of Cancer. Journal International Du Cancer
Weikang ZhangQing-Yi Wei
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
E Bruera, C Sweeney
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Yang ZhaoDavid C Christiani
© 2022 Meta ULC. All rights reserved