Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Acta Pharmacologica Sinica
Yiming YuanZhiguang Su

Abstract

Adiponectin has been implicated in the development of chronic obstructive pulmonary disease (COPD). The CDH13 gene encodes T-cadherin that is an adiponectin receptor, and genetic variants of CDH13 determine blood adiponectin levels. The aim of this study was to investigate the effects of CDH13 variants on COPD susceptibility in a Chinese population. Ten single-nucleotide polymorphisms (SNP) in CDH13 were screened using the SNaPshot method in 279 COPD patients and 367 control subjects. Association of genotypes or haplotypes constructed from these loci with COPD was analyzed in different genetic models. Among the 10 SNPs tested, rs4783244 and rs12922394 exhibited significant differences in allele or genotype frequencies between COPD patients and control subjects, whereas 8 other SNPs did not. The minor allele T was associated with decreased risk of COPD in the recessive model at rs4783244 (OR=0.42, P=0.023) and in the dominant model at rs12922394 (OR=0.70, P=0.022). The genotype TT at either rs4783244 or rs12922394 was associated with a significantly low level of plasma adiponectin when compared to genotypes GG and CC (P<0.05). Haplotypes GC in block 1 (rs4783244-rs12922394) as well as GTAC and ATGT in block 3 (rs4783266-rs116405...Continue Reading

References

Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Jian-Qing HeAndrew J Sandford
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher HugHarvey F Lodish
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jun 19, 2007·American Journal of Respiratory and Critical Care Medicine·Nanshan ZhongPixin Ran
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina MillerDavid H Broide
Nov 17, 2009·American Journal of Respiratory Cell and Molecular Biology·Ming ZhuStephanie A Shore
Nov 3, 2010·The Journal of Clinical Investigation·Martin S DenzelBarbara Ranscht
Jan 12, 2012·The International Journal of Biochemistry & Cell Biology·Aurora DanieleAndrea Bianco
Feb 9, 2012·Lancet·Marc DecramerMarc Miravitlles
Mar 20, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Sharon R Rosenberg, Ravi Kalhan
Apr 27, 2012·PloS One·John W ColeJeffrey R O'Connell
Aug 11, 2012·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboRoberto Rodriguez-Roisin
Jun 20, 2013·American Journal of Respiratory and Critical Care Medicine·Brendan J CarolanRussell P Bowler
Apr 2, 2014·International Journal of Medical Sciences·Yiping LiChunjie Xiao
Jun 20, 2014·Journal of Human Genetics·Yiming YuanZhiguang Su
Dec 17, 2014·Metabolism: Clinical and Experimental·Matthias Blüher, Christos S Mantzoros

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

© 2021 Meta ULC. All rights reserved