PMID: 8614983Feb 1, 1996Paper

Genetic variants of human T-lymphotrophic virus type II in American Indian groups

Virology
R J BiggarB H Hahn

Abstract

The human T-lymphotropic virus type II (HTLV-II) is found in many New World Indian groups in North and South America and may have entered the New World from Asia with the earliest migration of ancestral Amerindians over 15,000 years ago. To characterize the phylogenetic relationships of HTLV-II strains infecting geographically diverse Indian populations, we used polymerase chain reaction to amplify HTLV-II sequences from lymphocytes of seropositive Amerindians from Brazil (Kraho, Kayapo, and Kaxuyana), Panama (Guaymi), and the United States (the Navajo and Pueblo tribes of the southwestern states and the Seminoles of Florida). Sequence analysis of a 780-base pair fragment (located between the env gene and the second exons of tax/rex) revealed that Amerindian viruses clustered in the same two genetic subtypes (IIa and IIb) previously identified for viruses from intravenous drug users. Most infected North and Central American Indians had subtype IIb, while HTLV-II infected members of three remote Amazonian tribes clustered as a distinct group within subtype IIa. These findings suggest that the ancestral Amerindians migrating to the New World brought at least two genetic subtypes, IIa and IIb. Because HTLV-II strains from Amazonia...Continue Reading

Citations

Sep 19, 2003·AIDS Research and Human Retroviruses·Dimas Tadeu Covas, Simone Kashima
Jul 2, 2005·AIDS Research and Human Retroviruses·Bernadette Catalan-SoaresUNKNOWN GIPH (Interdisciplinary HTLV-I/II Research Group)
Mar 15, 2013·AIDS Research and Human Retroviruses·Mariana Cavalheiro MagriAdele Caterino-de-Araujo
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·M SalemiA M Vandamme
Jan 10, 2002·Journal of Medical Virology·Edimilson A SilvaAna Carolina P Vicente
Feb 5, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Arthur Paiva, Jorge Casseb
Jan 29, 2002·Revista Da Sociedade Brasileira De Medicina Tropical·R IshakM O Guimarães Ishak
Sep 16, 2003·Cadernos de saúde pública·Ricardo IshakMarluísa de Oliveira Guimarães Ishak
Jul 24, 2008·Journal of Autism and Developmental Disorders·David Williams, Francesca Happé
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·W Heneine
Apr 15, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·R B LalF Black
Mar 31, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Denise Duizit ColinJosé Tavares-Neto
Mar 2, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Philippe LemeyAnne-Mieke Vandamme

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