Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Hui PengFeng Li

Abstract

Several studies have reported the association of PTPN2 gene with type 1 diabetes mellitus (T1DM) in many populations but not in the Chinese Han population. Therefore, the goal of our study was to replicate the reported association between 2 single-nucleotide polymorphisms (SNPs; rs478582 and rs2542151) in the PTPN2 gene and T1DM in Chinese Han children. This case-control study included 141 Chinese Han children with T1DM and 282 healthy controls. Genetic variants of rs478582 and rs2542151 in PTPN2 gene were performed by PCR amplification followed by restriction fragment length polymorphism method. No difference was observed in association of rs478582 in The PTPN2 gene and T1DM. The distribution of allele frequency of rs2542151 differed significantly between T1DM patients and healthy controls (OR, 0.6; 95%CI: 0.44 to 0.95; and P=0.024). Dominant model of rs254215 also was associated with T1DM (OR, 0.6; 95%CI: 0.40 to 0.96; and P=0.032). Younger age at onset in G carriers appeared to increase the risk for T1DM (P=0.030). The findings suggested that rs2542151 SNP in The PTPN2 gene was associated with T1DM in Chinese Han children. Further studies with larger sample sizes involving gene-gene interactions are urgently needed.

References

Nov 28, 2002·Diabetes·Edwin A M Gale
Dec 17, 2008·The New England Journal of Medicine·Deborah J SmythJohn A Todd
May 12, 2009·Nature Genetics·Jeffrey C BarrettUNKNOWN Type 1 Diabetes Genetics Consortium
Mar 31, 2010·Nature Reviews. Endocrinology·Didier Hober, Pierre Sauter
Jan 20, 2011·Immunogenetics·Laura Espino-PaisanJose Luis Santiago
May 28, 2011·Immunological Investigations·Youssef M MosaadBasem S El-Deek
Jan 31, 2012·Genome Medicine·Corinne Richard-Miceli, Lindsey A Criswell
Mar 20, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lang WuGloria M Petersen
Jun 11, 2014·International Journal of Immunogenetics·N KumarN K Mehra

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Citations

Oct 19, 2017·Nature Reviews. Nephrology·Mia J SmithJohn C Cambier

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SDS
SPSS

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