Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma

Carcinogenesis
Chunying LiQingyi Wei

Abstract

Sunlight causes various kinds of DNA damage, including oxidative lesions that are removed effectively by the base excision repair (BER) pathway, in which ADPRT, XRCC1 and APE1 play a key role. However, genetic variation in these genes may alter their functions. We hypothesized that ADPRT, XRCC1 and APE1 polymorphisms are associated with risk of cutaneous melanoma (CM). In a hospital-based case-control study of 602 CM patients and 603 cancer-free control subjects frequency matched on age, sex and ethnicity, we genotyped for three non-synonymous single nucleotide polymorphisms (SNPs) (i.e. the ADPRT Val762Ala, XRCC1 Arg399Gln and APE1Asp148Glu) and assessed their associations with risk of CM. We found no significant difference in the allele frequencies between cases and controls for any of these three SNPs. However, we found that, compared with the APE1 Asp/Asp genotype, a significantly decreased risk of CM was associated with the APE1 Asp/Glu [adjusted odds ratio (OR), 0.60; 95% confidence interval (CI), 0.41-0.86], Glu/Glu (OR, 0.58; 95% CI, 0.38-0.88) and combined APE1 Asp/Glu+Glu/Glu (OR, 0.59; 95% CI, 0.42-0.83) genotypes, but not for other XRCC1 variant genotypes. Moreover, there was evidence for a possible gene-gene intera...Continue Reading

Citations

Dec 24, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Avinash BardiaAleem A Khan
Feb 2, 2013·Molecular Aspects of Medicine·Nicola J Curtin, Csaba Szabo
Oct 11, 2011·Nature Genetics·Stuart MacgregorNicholas K Hayward
Mar 9, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·M NorvalJ C van der Leun
Nov 22, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiaohong ZhangWei Zou
Jul 17, 2007·Journal of Epidemiology and Community Health·Somdat MahabirSteven D Mark
Jan 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhiyong ZhaoYuchen Ma
Sep 28, 2010·British Journal of Neurosurgery·Elif YosunkayaGonul Kanigur-Sultuybek
May 16, 2012·Journal of the American Academy of Dermatology·Katherine A WardMaria K Hordinsky
Jul 6, 2010·Mutation Research·Adina FiglRajiv Kumar
Jan 9, 2010·Cancer Treatment Reviews·Rachel Abbotts, Srinivasan Madhusudan
Jul 14, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pervin VuralMüjdat Uysal
Mar 11, 2011·The Journal of Investigative Dermatology·David SchramaJürgen C Becker
Apr 6, 2012·The Journal of Investigative Dermatology·Matthew H LawNicholas K Hayward
Sep 23, 2006·The Journal of Investigative Dermatology·Chunying LiQingyi Wei
Jun 15, 2007·Molecular Aspects of Medicine·Melissa L Fishel, Mark R Kelley
Aug 28, 2009·Cell Biochemistry and Function·Semra Doğru-AbbasoğluMüjdat Uysal
Jan 10, 2008·International Journal of Cancer. Journal International Du Cancer·Chunying LiQingyi Wei
May 11, 2013·Pigment Cell & Melanoma Research·Salina M TorresMarianne Berwick
Mar 1, 2012·Journal of Surgical Oncology·Isabelle Joyce de Lima Silva-FernandesSilvia Helena Barem Rabenhorst
Feb 1, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jin Sol LeeHyoung Doo Shin
Jun 7, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maider Ibarrola-VillavaGloria Ribas
Jun 13, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Concetta SantonocitoEttore Capoluongo
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·Miral Dizdaroglu
Sep 23, 2014·Oxidative Medicine and Cellular Longevity·Jae Sung ParkYoung Rok Seo
Sep 6, 2018·PloS One·Kashif BashirMahmood Akhtar Kayani
Jan 27, 2011·British Journal of Cancer·M Z MohammedS Madhusudan
Jan 11, 2007·Carcinogenesis·Joanne E PoveyDavid W Melton
Nov 22, 2016·Molecular Carcinogenesis·Magda CuchraIreneusz Majsterek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Neurosurgery
Elif YosunkayaGonul Kanigur-Sultuybek
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Yawei ZhangMontserrat García-Closas
© 2022 Meta ULC. All rights reserved