PMID: 9170002May 1, 1997Paper

Genetic variants of the renin-angiotensin system and ambulatory blood pressure in essential hypertension

Journal of Hypertension
J BeigeA M Sharma

Abstract

To examine whether the angiotensinogen M235T and angiotensin converting enzyme insertion/deletion (I/D) variants are related to the severity of hypertension in patients with established essential hypertension. A cross-sectional study. The hypertension clinic of the Benjamin Franklin University Hospital, Free University of Berlin. Three hundred and forty-three consecutive Caucasian patients who presented with treated or untreated (n = 115) hypertension were enrolled into the study. Twenty-two patients were excluded from analysis because they had secondary hypertension. Angiotensinogen M235T and angiotensin-converting enzyme I/D genotypes, 24 h ambulatory blood pressure values, the number of antihypertensive medications administered and left ventricular dimensions assessed by two-dimensional echocardiography. Neither the angiotensinogen nor the angiotensin converting enzyme genotype was related significantly to the average ambulatory blood pressure and left ventricular dimensions in hypertensives. Furthermore, neither the number of antihypertensive medications administered to treated patients nor blood pressure levels in untreated patients (n = 115) differed significantly between the genotypic groups. These results do not support...Continue Reading

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Citations

Nov 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Gysèle S BleuminkBruno H Ch Stricker
Feb 19, 2008·British Journal of Clinical Pharmacology·Marcin Zakrzewski-JakubiakJacques Turgeon
Jun 30, 2005·The Veterinary Journal·A R Michell
Sep 10, 2015·International Journal of Hypertension·Daméhan TchelougouJacques Simpore
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·N PadmanabhanJ M Connell
Apr 1, 1999·Journal of Hypertension·J A StaessenR Fagard
Jul 15, 1999·Journal of Hypertension·U SchorrA M Sharma
Oct 24, 2002·Critical Care Medicine·Gere Sunder-PlassmannManuela Födinger

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