Genetic variants of TREML2 are associated with HLA-B27-positive ankylosing spondylitis

Gene
Yuan FengChangqing Zeng

Abstract

Although ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the precise genetic mechanism underlying the disease remains elusive. Here, we investigate the disease-causing mutations in a large AS family with distinguished complexity, consisting of 23 patients covering four generations and exhibiting a mixed HLA-B27 (+) and (-) status. Linkage analysis with 32 members using three methods and whole-exome sequencing analysis with three HLA-B27 (+) patients, one HLA-B27 (-) patient, and one healthy individual did not identify a mutation common to all of the patients, strongly suggesting the existence of genetic heterogeneity in this large pedigree. However, if only B27-positive patients were analyzed, the linkage analysis located a 22-Mb region harboring the HLA gene cluster in chromosome 6 (LOD = 4.2), and the subsequent exome analysis identified two non-synonymous mutations in the TREML2 and IP6K3 genes. These genes were resequenced among 370 sporadic AS patients and 487 healthy individuals. A significantly higher mutation frequency of TREML2 was observed in AS patients (1.51% versus 0.21%). The results obtained for the AS pedigree and sporadic patients suggest that mutation of TREML2 is a major factor leading ...Continue Reading

Citations

Jan 9, 2019·Frontiers in Immunology·Félicie CostantinoHenri-Jean Garchon
Oct 8, 2020·Journal of Personalized Medicine·Roberto Díaz-PeñaAlejandro Lucia
Jun 22, 2021·Frontiers in Genetics·Félicie CostantinoMaxime Breban

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