Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Nicholas J OllberdingLoïc Le Marchand

Abstract

Increased exposure of colonic and rectal epithelial cells to the promitotic and antiapoptotic effects of insulin and insulin-like growth factors (IGF) is hypothesized to increase colorectal cancer risk. In a case-control study nested within the Multiethnic Cohort, we attempted to replicate associations for five genetic variants associated with IGF system biomarkers, insulin, or glucose and to examine their association with the risk of colorectal cancer. In a subset of participants, the association between circulating biomarkers and colorectal cancer risk was examined. Unconditional logistic regression was used to calculate ORs and 95% confidence intervals (CI) for genetic variants (1,954 cases/2,587 controls) and serum biomarkers (258 cases/1,701 controls). Associations with circulating biomarkers were replicated in the Multiethnic Cohort for IGF1 rs35767 and for IGFBP3 rs2854744, rs2854746, and rs3110697 (P < 0.05). Homozygous carriers of the glucokinase regulator (GCKR) rs780094 variant T-allele were at a decreased risk of colorectal cancer (OR, 0.77; 95% CI, 0.64-0.92). In risk factor-adjusted models, participants with the highest prediagnostic IGF-II levels were at an increased risk [OR (T1 vs. T3), 1.58; 95% CI, 1.09-2.28;...Continue Reading

References

Jan 1, 1989·American Journal of Epidemiology·R M Mickey, S Greenland
Dec 24, 1997·Proceedings of the Society for Experimental Biology and Medicine·P D LeeD R Powell
Jul 7, 1999·Journal of the National Cancer Institute·R E SchoenP J Savage
Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·O ManousosC Mantzoros
Mar 1, 2000·American Journal of Epidemiology·L N KolonelF S Nagamine
Jul 4, 2002·Journal of the National Cancer Institute·Manjinder S SandhuEdward L Giovannucci
Dec 6, 2002·Endocrine Reviews·Sue M Firth, Robert C Baxter
Aug 26, 2003·American Journal of Epidemiology·Abraham M Y NomuraMichael N Pollak
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·Annekatrin LukanovaRudolf Kaaks
Jan 22, 2004·International Journal of Cancer. Journal International Du Cancer·Pär StattinEgil Jellum
Apr 8, 2004·Journal of the National Cancer Institute·Jing MaMeir J Stampfer
Oct 28, 2004·Epidemiologic Perspectives & Innovations : EP+I·Jay S KaufmanSol Kaufman
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Esther K WeiEdward Giovannucci
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Loïc Le MarchandLynne R Wilkens
May 17, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stacey A MissmerSusan E Hankinson
Aug 26, 2006·Endocrine Reviews·Amir Abbas SamaniPnina Brodt
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Katherine Delellis HendersonLoïc Le Marchand
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul J LimburgDemetrius Albanes
Feb 3, 2007·International Journal of Cancer. Journal International Du Cancer·Tetsuya OtaniUNKNOWN Japan Public Health Center-based Prospective Study Group
Mar 21, 2007·International Journal of Cancer. Journal International Du Cancer·Mazda JenabRudolf Kaaks
Apr 28, 2007·Science·UNKNOWN Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
Sep 20, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T StocksP Stattin
Nov 23, 2007·Cancer Detection and Prevention·Sonali PechlivanisAsta Försti
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Caroline DiorioMichael Pollak
May 10, 2008·Archives of Physiology and Biochemistry·Paola Pisani
Nov 26, 2008·Nature Reviews. Cancer·Michael Pollak
Feb 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aimee A D'AloisioDonna D Baird
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Xuefen SuRulla M Tamimi
Sep 29, 2009·Cancer Causes & Control : CCC·Elisabeth FeikAndrea Gsur
Oct 29, 2009·Human Molecular Genetics·Pim van der HarstGerjan Navis

❮ Previous
Next ❯

Citations

Oct 5, 2013·American Journal of Epidemiology·Chiranjeev DashLucile L Adams-Campbell
May 1, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mai YamauchiShuji Ogino
Feb 12, 2013·Current Nutrition Reports·Krasimira AleksandrovaTobias Pischon
Oct 21, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kalliopi Pazaitou-PanayiotouChristos S Mantzoros
Jul 30, 2014·International Journal of Cancer. Journal International Du Cancer·Akihisa HidakaUNKNOWN JPHC Study Group
Sep 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei ZhaoMeng-Zhong Liu
Dec 21, 2014·BMC Cancer·Danielle J CrawleyMieke Van Hemelrijck
Mar 17, 2015·Frontiers in Endocrinology·Adam Pickard, Dennis J McCance
Dec 27, 2016·World Journal of Gastroenterology : WJG·Patrizia FerroniMario Roselli
Apr 19, 2017·Oncotarget·Maria Adelaide MariniGiorgio Sesti
Sep 6, 2014·Molecular Biology Reports·Noyko S StanilovSpaska A Stanilova
Aug 18, 2018·Scientific Reports·Gaia C ManninoGiorgio Sesti
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Joshi PankajSang-Ah Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.