Asthma is caused by a combination of poorly understood genetic and environmental factors. We have systematically mapped the effects of single nucleotide polymorphisms (SNPs) on the presence of childhood onset asthma by genome-wide association. We characterized more than 317,000 SNPs in DNA from 994 patients with childhood onset asthma and 1,243 non-asthmatics, using family and case-referent panels. Here we show multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P value of P < 10(-12). In independent replication studies the 17q21 locus showed strong association with diagnosis of childhood asthma in 2,320 subjects from a cohort of German children (P = 0.0003) and in 3,301 subjects from the British 1958 Birth Cohort (P = 0.0005). We systematically evaluated the relationships between markers of the 17q21 locus and transcript levels of genes in Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines from children in the asthma family panel used in our association study. The SNPs associated with childhood asthma were consistently and strongly associated (P < 10(-22)) in cis with transcript levels of ORMDL3, a member of a...Continue Reading
Baby swimming and disinfection by-products in swimming pools. Communication from the Federal Environment Agency following the swimming and wading pool water commission hearings of the Federal Ministry of Health at the Federal Environment Agency
From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases
Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection
Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines
Haplotype in the IBD5 region is associated with refractory Crohn's disease in Slovenian patients and modulates expression of the SLC22A5 gene
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Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study
Prenatal and childhood infections: implications for the development and treatment of childhood asthma
Investigation of the fine structure of European populations with applications to disease association studies
Significant evidence for linkage to chromosome 5q13 in a genome-wide scan for asthma in an extended pedigree resource
Joint analysis of tightly linked SNPs in screening step of genome-wide association studies leads to increased power
A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31-32 region and asthma
First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.
Allergies & Environmental Factors
Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.