Genetic Variants That Are Associated with Neuropsychiatric Systemic Lupus Erythematosus

The Journal of Rheumatology
Roger C HoMelvyn W Zhang

Abstract

While genetic risks have been implicated in systemic lupus erythematosus (SLE), the involvement of various genotypes in neuropsychiatric SLE (NPSLE) remains uncertain. The present metaanalysis aimed to combine data from different studies and evaluate the association between each genotype and the risk of developing NPSLE. Studies were searched and retrieved from online databases (PubMed, EMBASE, BIOSIS, and ScienceDirect). Case-control studies were chosen if they reported genotype frequencies of the γ Fc region (FCγR) receptors II-A, III-A, and III-B; tumor necrosis factor-α (TNF-α); mannan-binding lectin (MBL); integrin alpha M (ITGAM); interleukin (IL) 1, IL-1β, and IL-6; IL-10 promoter; and vitamin D genes. The OR were used to assess the strength of this association between patients with NPSLE and SLE. A total of 33 studies were considered in this metaanalysis. The results suggest that these genotypes demonstrated a significant association with NPSLE: the homozygous FCγR IIIa 158 FF genotype (OR 1.89, p = 0.03 for FF vs VV + FV), heterozygous FCγR IIIb NA1/2 genotype (OR 2.14, p = 0.03 for NA1/2 vs NA1/1; OR 1.81, p = 0.04 for NA1/2 vs NA1/1 + NA2/2), and homozygous ITGAM rs1143679 HH genotype (OR 3.39, p = 0.04 for HH vs RH;...Continue Reading

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Citations

Nov 23, 2016·Nature Reviews. Rheumatology·George C TsokosKathleen E Sullivan
Oct 7, 2017·Current Rheumatology Reports·Yun Deng, Betty P Tsao
Jul 20, 2018·International Journal of Environmental Research and Public Health·Russell B C LimRoger C M Ho
Jun 5, 2020·The Journal of International Medical Research·Yukai WangZhong Xin Xu
Aug 30, 2017·Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·Melvyn W B ZhangRoger C M Ho
Aug 5, 2020·Journal of Translational Medicine·Zijian LiYanxia Guo

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