Genetic variation and phylogenetic relationships of 22 porcine reproductive and respiratory syndrome virus (PRRSV) field strains based on sequence analysis of open reading frame 5

Archives of Virology
V G AndreyevK M Lager

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) strains from 13 states in the United States, Guatemala and Canada were used to compare the envelope glycoprotein gene (ORF 5) nucleotide and deduced amino acid sequences. The gene was the same size, 603 nt, for all the 22 field strains. These strains had 89-94% amino acid identity compared to reference strain VR 2332. A putative signal sequence and cleavage site between residues 31 and 32 was identified and three potential glycosylation sites were present on all but two strains. Hydrophobicity/hydrophilicity and surface probability analyses reveal a primary structure for the envelope glycoprotein (E protein) with six potential surface regions that could be antigenic sites. Similar E protein structural features are conserved for the prototype European PRRSV-Lelystad virus.

Citations

Oct 19, 2006·Biochemical Genetics·Jian ChenYao-Zhou Zhang
May 18, 2006·Emerging Infectious Diseases·Porntippa LekcharoensukJürgen A Richt
Aug 21, 2015·The Journal of Veterinary Medical Science·Byoung-Joo SeoWon-Il Kim
May 26, 2009·Vaccine·Tjeerd G KimmanNorbert Stockhofe-Zurwieden
Feb 26, 2011·Microbiology and Immunology·Hiroshi IsekiHiroshi Tsunemitsu
Oct 28, 2004·Veterinary Immunology and Immunopathology·Udeni B R Balasuriya, N James MacLachlan
Oct 28, 2004·Veterinary Immunology and Immunopathology·Sang-Myeong LeeSteven B Kleiboeker
Oct 28, 2004·Veterinary Immunology and Immunopathology·O J Lopez, F A Osorio

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