Genetic variation and plasma creatine kinase activity

Acta geneticae medicae et gemellologiae
J B Whitfield, N G Martin

Abstract

The distribution of plasma creatine kinase (CK; E.C.2.7.3.2) is known to be skewed, and this has made it difficult to analyse the sources of variation. We have studied plasma CK in 206 pairs of twins and have analysed the results after separating them into what appear to be two Gaussian frequency distributions. The results in the main distribution (CK less than 300 iu/1) are apparently affected by genetic factors common to both men and women, and by environmental factors which are of much greater effect in men. The tendency for some men to have very high CK values may also have a genetic basis.

References

Dec 1, 1978·Heredity·L J EavesN G Martin
Apr 1, 1978·Clinical Genetics·H Y MeltzerR Belmaker
Mar 1, 1985·Behavior Genetics·N G MartinA V Wilks
Jun 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Y Meltzer
Apr 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·P D Griffiths
Jan 1, 1980·Acta geneticae medicae et gemellologiae·P ClarkeR J Walsh
Sep 14, 1963·JAMA : the Journal of the American Medical Association·R G HOFFMANN

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