Genetic variation at minisatellite loci D1S7, D4S139, D5S110 and D17S79 among three population groups of eastern India

Journal of Genetics
R Dutta, V K Kashyap

Abstract

Genetic variation at four minisatellite loci D1S7, D4S139, D5S110 and D17S79 in three predominant population groups of eastern India, namely Brahmin, Kayastha and Garo, are reported in this study. The Brahmin and Kayastha are of Indo-Caucasoid origin while the Garo community represents the Indo-Mongoloid ethnic group. The methodology employed comprised generation of HaeIII-restricted fragments of isolated DNA, Southern blotting, and hybridization using chemiluminescent probes MS1, pH30, LH1 and V1 for the four loci. All four loci were highly polymorphic in the population groups. Heterozygosity values for the four loci ranged between 0.68 and 0.95. Neither departure from Hardy Weinberg expectations nor evidence of any association across alleles among the selected loci was observed. The gene differentiation value among the loci is moderate (GST = 0.027). A neighbour-joining tree constructed on the basis of the generated data shows very low genetic distance between the Brahmin and Kayastha communities in relation to the Garo. Our results based on genetic distance analysis are consistent with results of earlier studies based on serological markers and linguistic as well as morphological affiliations of these populations and their I...Continue Reading

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Citations

Jun 19, 2007·Genomics, Proteomics & Bioinformatics·Qiao-Fang HouSheng-Bin Li
Apr 22, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·V K KashyapT S Vasulu
Oct 12, 2002·Transfusion·M C A De UngriaS C Halos
Mar 13, 2020·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·W Campos-PerezE Martinez-Lopez
Aug 3, 2011·Molecular Biology Reports·Ruifang SunShengbin Li

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