Genetic Variation at the ADAMTS7 Locus is Associated With Reduced Severity of Coronary Artery Disease.

Journal of the American Heart Association
Kenneth ChanRiyaz S Patel

Abstract

Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using histological, angiographic, and clinical outcomes data. The lead CAD-associated single-nucleotide polymorphism rs3825807 at the ADAMTS7 locus was genotyped. The G allele (reduced ADAMTS7 function) was associated with a smaller fibrous cap (P=0.017) and a smaller percentage area of α-actin (smooth muscle cell marker) in the intima (P=0.017), but was not associated with calcification or plaque thickness, following ex vivo immunohistochemistry analysis of human coronary plaques (n=50; mean age 72.2±11.3). In two independent cohorts (Southampton Atherosclerosis Study [n=1359; mean age 62.5±10.3; 70.1% men] and the Emory Cardiovascular Biobank [EmCAB; n=2684; mean age 63.8±11.3; 68.7% men]), the G allele was associated with 16% to 19% lower odds of obstructive CAD (Southampton Atherosclerosis Study: odds ratio, 0.81; 95% confidence interval, 0.67-0.98; EmCAB: odds ratio, 0.84; 95% confidence interval, 0.75-0.95) with similar effects ...Continue Reading

References

Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Jun 12, 2004·The Journal of Biological Chemistry·Robert P T SomervilleSuneel S Apte
Oct 17, 2012·American Heart Journal·Ian J NeelandArshed A Quyyumi
Dec 4, 2012·Nature Genetics·Panos DeloukasNilesh J Samani
Jul 21, 2015·Molecular Genetics and Genomics : MGG·Ling YouWei Cui

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Citations

Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sunhee JungGeum-Sook Hwang
Jun 29, 2021·Circulation Research·Taiji MizoguchiPatrick T Ellinor

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Methods Mentioned

BETA
coronary
coronary artery bypass
coronary bypass

Software Mentioned

SAS
EmoryCAB
Power
EmCAB
Sequenom
SPSS
Haploview

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