Oct 29, 2018

Genetic variation for ontogenetic shifts in metabolism underlies physiological homeostasis in Drosophila

BioRxiv : the Preprint Server for Biology
Omera Bashir MatooKristi L Montooth

Abstract

Organismal physiology emerges from metabolic pathways and structures that can vary across development and among individuals. Here we tested whether genetic variation at one level of physiology can be buffered at higher levels during development by the inherent capacity for homeostasis in physiological systems. We found that the fundamental scaling relationship between mass and metabolic rate, as well as the oxidative capacity per mitochondria, differed significantly across development in the fruit fly Drosophila . However, mitochondrial respiration rate was maintained across development at similar levels. Furthermore, genotypes clustered into two types—those that switched to aerobic, mitochondrial ATP production before the second instar and those that relied on anaerobic production of ATP via glycolysis through the second instar. Despite genetic variation for the timing of this metabolic shift, second-instar metabolic rate was more robust to genetic variation than was the metabolic rate of other instars. We also found that a mitochondrial-nuclear genotype with disrupted mitochondrial function both increased aerobic capacity more through development and relied more heavily on anaerobic ATP production relative to wildtype genotyp...Continue Reading

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Mentioned in this Paper

Metabolic Process, Cellular
Buffers
Strategy
Mitochondrial Inheritance
Defense Mechanisms
Cell Respiration
Free Radicals
Drosophila
Mitochondrial Membranes
Radicals (chemistry)

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