Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.

Carcinogenesis
Martha L SlatteryRoger K Wolff

Abstract

Serine/threonine protein kinase 11 (STK11) and phosphatase tensin homolog deleted on chromosome 10 (PTEN) link insulin sensitivity and metabolic signaling to inflammation and other hormonal factors and colorectal cancer. We evaluate genetic variation in nine genes in a candidate pathway as follows: STK11 (3 tagSNPs), PTEN (9 tagSNPs), FRAP1 (mTOR) (4 tagSNPs), TSC1 (14 tagSNPs), TSC2 (8 tagSNPs), Akt1 (2 tagSNPs), PIK3CA (7 tagSNPs), PRKAA1 (13 tagSNPs) and PRKAG2 (68 tagSNPs) in two population-based case-control studies of colon (n = 1574 cases, 1940 controls) and rectal (n = 91 cases, 999 controls) cancer. FRAP1, PRKAA1, PRKAG2 and TSC2 genes were significantly associated with colon cancer; risk estimates ranged from 1.21 [95% confidence interval (CI) 1.05-1.38] for FRAP1rs1057079 for the AG/GG genotype to 1.51 (95% CI 1.09-2.09) for PRKAG2rs9648723 CC genotype. PIK3CA, PRKAG2, PTEN, STK11 and TSC1 were significantly associated with rectal cancer overall. The strongest association was observed for PIK3CA rs7651265 GG genotype (odds ratio 2.32 95% CI 1.02-5.30). FRAP1 was associated with microsatellite instability (MSI)+ colon tumors; PRKAA1, CpG island methylator phenotype (CIMP)+ and MSI+ colon tumors; PRKAG2 and KRAS2 colon...Continue Reading

References

Jul 1, 1990·Statistics in Medicine·Y Hochberg, Y Benjamini
Dec 1, 1994·American Journal of Epidemiology·S EdwardsJ D Potter
Jul 1, 1994·Journal of the American Dietetic Association·M L SlatteryR Kerber
Mar 21, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B J CaanS M Edwards
Dec 5, 1998·Biochimica Et Biophysica Acta·D R Alessi, C P Downes
Nov 18, 2000·Journal of the National Cancer Institute·M L SlatteryW S Samowitz
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Wade S SamowitzMartha L Slattery
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Jan 4, 2003·The Journal of Biological Chemistry·Baldwin C MakRaymond S Yeung
Jan 28, 2003·Biochemical Society Transactions·B ViolletS Vaulont
Apr 24, 2003·Cancer Causes & Control : CCC·M L SlatteryJohn D Potter
Jul 29, 2003·American Journal of Epidemiology·M L SlatteryD Schaffer
Nov 15, 2003·Current Biology : CB·Angela WoodsDavid Carling
Dec 19, 2003·American Journal of Human Genetics·Christopher S CarlsonDeborah A Nickerson
Jan 20, 2004·Trends in Biochemical Sciences·David Carling
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reuben J ShawLewis C Cantley
Mar 27, 2004·Current Biology : CB·David Carling
Jul 21, 2004·Cancer Cell·Reuben J ShawLewis C Cantley
Sep 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L A DeGraffenriedM Hidalgo
Oct 29, 2004·Journal of Cell Science·D Grahame Hardie
Dec 14, 2004·Current Biology : CB·Tracey L Fisher, Morris F White
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryWade S Samowitz
Oct 30, 2007·American Journal of Human Genetics·Karen N Conneely, Michael Boehnke
Dec 13, 2007·Cell Cycle·Dung-Fang Lee, Mien-Chie Hung
Mar 26, 2009·Cancer Research·Neil Duncan ShephardAngela Cox
May 20, 2009·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryWade Samowitz
Jul 3, 2009·Diseases of the Colon and Rectum·Martha L SlatteryWade Samowitz
Nov 7, 2009·Cancer Prevention Research·Martha L Slattery, F A Fitzpatrick
Dec 4, 2009·Oncogene·S Menon, B D Manning
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Karen CurtinMartha L Slattery

❮ Previous
Next ❯

Citations

Jun 28, 2013·Carcinogenesis·Cindy M ChangUNKNOWN Genetics and Epidemiology of Colorectal Cancer Consortium
Feb 5, 2013·Journal of the National Cancer Institute·Xiang ShuXifeng Wu
Apr 26, 2014·World Journal of Gastroenterology : WJG·Xiao-Wen Wang, Yan-Jie Zhang
Sep 13, 2012·Journal of the American Medical Informatics Association : JAMIA·Zhenshu WenLuonan Chen
Feb 12, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aaron E HoffmanYong Zhu
Mar 26, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mei-Ling ZhuQing-Yi Wei
Nov 19, 2015·Carcinogenesis·Ting-Yuan David ChengLynn Rosenberg
Dec 23, 2011·Journal of Digestive Diseases·Jing Nan LiJia Ming Qian
Feb 22, 2012·Molecular Carcinogenesis·Andrew J PellattMartha L Slattery
Jun 18, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fangyuan JingKun Chen
Apr 24, 2014·BioMed Research International·Chiou-Feng LinChiung-Wen Tsao
May 18, 2016·International Journal of Molecular Sciences·Simona GranataGianluigi Zaza
Apr 24, 2015·PloS One·Kyoko KakumotoChitose Oneyama
Mar 27, 2015·Annals of Saudi Medicine·Rowyda N Alharithy
May 14, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Baoqi DuanZhaoqing Xi
Sep 28, 2018·Tissue Engineering. Part a·Lindsey T SaldinStephen F Badylak
Sep 3, 2016·Oncotarget·Jineun KimSuk-Jo Kang
Apr 25, 2020·Thyroid : Official Journal of the American Thyroid Association·Chan Kwon JungYeun-Jun Chung
Jun 4, 2020·Journal of Clinical Laboratory Analysis·Cheng-Lin LiBao Zang
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Mohammadreza NassiriMohammad Doosti
Oct 27, 2017·Molecular Carcinogenesis·Martha L SlatteryJennifer S Herrick
Oct 21, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Z BinalB Altay
Nov 30, 2018·Frontiers in Pharmacology·Antony Brayan Campos-SalazarRosario Dominguez Crespo Hirata

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.