Genetic variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion

Hypertension
Katarzyna StolarzEuropean Project On Genes in Hypertension (EPOGH) Investigators

Abstract

Sympathetic tone increases with stimulation of the renin-angiotensin system and is under the influence of salt intake. In the European Project On Genes in Hypertension (EPOGH), we investigated whether polymorphisms in the genes encoding aldosterone synthase (CYP11B2 C-344T) and the type-1 angiotensin II receptor (AT1R A1166C) affect the autonomic modulation of heart rate at varying levels of salt intake. We measured the low frequency (LF) and high frequency (HF) components of heart rate variability and their ratio (LF:HF) in the supine and standing positions in 1797 participants (401 families and 320 unrelated subjects) randomly selected from 6 European populations, whose average urinary sodium excretion ranged from 163 to 245 mmol/d. In multivariate analyses with sodium excretion analyzed as a continuous variable, we explored the phenotype-genotype associations using generalized estimating equations and quantitative transmission disequilibrium tests. Across populations, there was no heterogeneity in the phenotype-genotype relations. The genotypic effects differed according to sodium excretion. In subjects with sodium excretion <190 mmol/d (median), supine heart rate, LF, and LF:HF increased and HF decreased with the number of ...Continue Reading

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Citations

Jul 22, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ruthie E AmirBasil S Lewis
Jul 22, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Amy K MottlKari E North
Dec 19, 2007·Pharmacogenomics·Yonghong Li, Andrew Grupe
Mar 2, 2006·Journal of Hypertension·Tatiana KuznetsovaUNKNOWN European Project on Genes in Hypertension Investigators
Dec 5, 2006·Journal of Hypertension·Silvia SookoianCarlos Jose Pirola
Aug 10, 2011·Journal of Hypertension·Michel E SafarJacques Blacher
Jun 10, 2009·Expert Review of Cardiovascular Therapy·Edoardo CasigliaAchille C Pessina
Apr 20, 2014·Blood Pressure·Yu JinUNKNOWN investigator-steered project on intravascular renal denervation for management of drug-resistant hypertension (INSPiRED) inv
Mar 27, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Edoardo Casiglia, Valérie Tikhonoff
Feb 25, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Edoardo Casiglia, Valérie Tikhonoff
Apr 26, 2018·European Journal of Preventive Cardiology·Edoardo CasigliaPaolo Palatini
Mar 2, 2011·Hypertension·Katarzyna Stolarz-Skrzypek
Mar 25, 2005·Physiological Reviews·Pierre MenetonGraham A MacGregor
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·A L T UusitaloJ Kaprio
Mar 23, 2019·Journal of Human Hypertension·Valérie TikhonoffPaolo Spinella
Sep 29, 2017·Frontiers in Public Health·Gernot Ernst
Jul 2, 2019·Journal of Nutritional Science and Vitaminology·Asuka SawaiOsamu Tochikubo

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