Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors

Cancer Causes & Control : CCC
J D FigueroaK A McGlynn

Abstract

Testicular germ cell tumors (TGCT) that arise in young men are composed of two histologic types, seminomas and nonseminomas. Risk patterns for the two types appear to be similar and may be related to either endogenous or exogenous hormonal exposures in utero. Why similar risk patterns would result in different histologic types is unclear, but could be related to varying genetic susceptibility profiles. Genetic variation in hormone metabolizing genes could potentially modify hormonal exposures, and thereby affect which histologic type a man develops. To examine this hypothesis, 33 single nucleotide polymorphisms (SNPs) in four hormone metabolism candidate genes (CYP1A1, CYP17A1, HSD17B1, HSD17B4) and the androgen receptor gene (AR) were genotyped. Associations with TGCT were evaluated among 577 TGCT cases (254 seminoma, 323 nonseminoma) and 707 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) study. There were no significant associations with TGCT overall based on a test using an additive model. However, compared to homozygotes of the most common allele, two nonredundant SNPs in CYP1A1 were inversely associated with nonseminoma: CYP1A1 promoter SNP rs4886605 OR = 0.75 (95% CI = ...Continue Reading

References

May 15, 1979·International Journal of Cancer. Journal International Du Cancer·B E HendersonM C Pike
Aug 1, 1996·Environmental Health Perspectives·J ToppariN E Skakkebaek
Jun 11, 1997·International Journal of Cancer. Journal International Du Cancer·E PetridouD Trichopoulos
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J A McLachlanM Negishi
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·H K WeirL Sugar
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Apr 5, 2001·Journal of the National Cancer Institute·W C StrohsnitterE E Hatch
Jan 5, 2002·Cancer Investigation·K A McGlynn
Oct 9, 2002·The Journal of Nutrition·Susan E McCannPeter G Shields
Dec 20, 2002·Cancer·Katherine A McGlynnRobert E Tarone
Jan 22, 2003·International Journal of Andrology·Richard M Sharpe
Nov 7, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y MiyoshiS Noguchi
Dec 19, 2003·American Journal of Human Genetics·Christopher S CarlsonDeborah A Nickerson
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Veronica Wendy SetiawanImmaculata De Vivo
Mar 31, 2004·Cytogenetic and Genome Research·L L CollinsC Chang
May 8, 2004·Molecular and Cellular Endocrinology·R MindnichJ Adamski
Dec 8, 2004·Molecular Human Reproduction·N KurahashiR Kishi
Mar 17, 2005·Bulletin of Environmental Contamination and Toxicology·J E DuffyJ T Zelikoff
Apr 9, 2005·International Journal of Cancer. Journal International Du Cancer·Michael J GarnerDaniel Krewski
Jun 4, 2005·Science·Matthew D AnwayMichael K Skinner
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Katherine A McGlynnMark A Klebanoff
Jul 29, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jay B SilkworthStephen B Hamilton
Aug 23, 2005·Cancer Letters·Yuki TsuchiyaTsuyoshi Yokoi
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jacqueline R StarrStephen M Schwartz
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Jan 20, 2006·Cancer·Sadhna ShankarXiao-Ou Shu
Aug 3, 2006·Annals of Epidemiology·Yawei ZhangKatherine A McGlynn
Nov 18, 2006·American Journal of Epidemiology·Katherine A McGlynnRalph L Erickson
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mark P PurdueKatherine A McGlynn

❮ Previous
Next ❯

Citations

Mar 1, 2012·Journal of Physiology and Biochemistry·Mirja RotinenIgnacio Encío
Mar 30, 2010·Asian Journal of Andrology·Jonatan AxelssonAleksander Giwercman
Mar 7, 2013·Human Molecular Genetics·Fredrick R SchumacherKatherine A McGlynn
May 27, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Juei-Chuan C Kang-SickelLeena A Nylander-French
May 17, 2011·Hematology/oncology Clinics of North America·Andreas Stang, Oliver Kuss
Mar 30, 2010·International Journal of Andrology·W KristiansenE L Aschim
Oct 1, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Åke VästermarkAleksander Giwercman
Nov 5, 2013·Critical Reviews in Oncology/hematology·Ludmila BoublikovaJan Trka
Dec 7, 2010·Gynecologic Oncology·Stalo KarageorgiImmaculata De Vivo
Feb 9, 2018·Oncotarget·Gaetano FacchiniMicaela Montanari
Apr 1, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Omid BeikiTahereh Moradi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.