Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent.

Human Genetics
Chad P GarnerSusan L Neuhausen

Abstract

The insulin-like growth factor (IGF) signaling pathway is thought to play a major role in the etiology of breast cancer. Although incidence rates of breast cancer overall are lower in African Americans than in Caucasians, African-American women have a higher incidence under age 40 years, are diagnosed with more advanced disease, and have poorer prognosis. We investigated the association of breast cancer and genetic variants in genes in the IGF signaling pathway in a population-based case-control study of African-American women. We found significant associations at a locus encompassing parts of the IGFBP2 and IGFBP5 genes on chromosome 2q35, which we then replicated in a case-control study of Nigerian women. Based on those initial findings, we genotyped a total of 34 single nucleotide polymorphisms (SNPs) across the region in both study populations. Statistically significant associations with breast cancer were observed across approximately 50 kb of DNA sequence encompassing three exons in the 3' end of IGFBP2 and three exons in the 3' end of IGFBP5. SNPs were associated with breast cancer risk with P values as low as P = 0.0038 and P = 0.01 in African-Americans and Nigerians, respectively. This study is the first to report asso...Continue Reading

References

Jul 28, 1995·International Journal of Cancer. Journal International Du Cancer·P F BruningA A Hart
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
Jan 1, 1996·Breast Cancer Research and Treatment·B J Trock
Oct 16, 1999·American Journal of Clinical Oncology·H AzizM Rotman
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·C ByrneF E Speizer
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·P TonioloA Zeleniuch-Jacquotte
Dec 13, 2000·The Journal of Pediatrics·J A YanovskiN G Sebring
Feb 24, 2001·American Journal of Public Health·A M Marbella, P M Layde
Sep 22, 2001·Endocrine-related Cancer·D Sachdev, D Yee
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Stacey A MissmerSusan E Hankinson
Oct 16, 2002·The Journal of Endocrinology·S Mohan, D J Baylink
Jan 23, 2003·Journal of Cell Science·Emma MarshmanMelissa Westwood
Jun 5, 2003·The Journal of Biological Chemistry·Alison J ButtRobert C Baxter
Jul 24, 2003·Annals of Epidemiology·Clement A AdebamowoOlufunmilayo I Olopade
Dec 19, 2003·American Journal of Human Genetics·Christopher S CarlsonDeborah A Nickerson
Jan 8, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D J FlintG J Allan
Jun 3, 2004·Journal of Molecular Endocrinology·B S SchüttM W Elmlinger
Jul 2, 2004·Nature Reviews. Cancer·Michael N PollakSusan E Hankinson
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Steven A Rosenzweig
Mar 26, 2005·Journal of Clinical Pathology·L-T BusundH Stalsberg
Jun 30, 2005·Breast Cancer Research and Treatment·Kerstin WagnerAsta Försti
Dec 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wei WangSue Ann Ingles
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Veronica Wendy SetiawanMatthew L Freedman
Mar 11, 2006·The Biochemical Journal·James BeattieDavid J Flint
Aug 12, 2006·Journal of Molecular Endocrinology·Klaus W FrommerMartin W Elmlinger
Oct 13, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Iona ChengMatthew L Freedman
Feb 3, 2007·Genetic Epidemiology·Juliet Chapman, David Clayton
Jun 15, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M González-Zuloeta LaddC M van Duijn

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Citations

Nov 30, 2010·Breast Cancer Research and Treatment·Yuan Chun DingSusan L Neuhausen
Nov 26, 2008·Journal of Mammary Gland Biology and Neoplasia·Claire M Perks, Jeff M P Holly
Aug 20, 2008·Breast Cancer Research : BCR·Mustafa AkkiprikWei Zhang
Jan 26, 2012·The HUGO Journal·Sarah E Ali-KhanAbdallah S Daar
Jul 29, 2010·Trends in Endocrinology and Metabolism : TEM·Emily Jane Gallagher, Derek LeRoith
Oct 11, 2008·International Journal of Cancer. Journal International Du Cancer·Anselm J HennisUNKNOWN Barbados National Cancer Study Group
Oct 7, 2008·Cancer·Joe HarfordUNKNOWN Breast Health Global Initiative Healthcare Systems Panel
Oct 30, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P KallioM Uusitupa
Sep 14, 2012·G3 : Genes - Genomes - Genetics·Antonella GalvanTommaso A Dragani
Mar 16, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joseph L UssetUNKNOWN Ovarian Cancer Association Consortium and the Australian Cancer Study
Mar 5, 2021·Frontiers in Oncology·Solomon O RotimiBodour Salhia

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