Genetic variation in matrix metalloproteinase MMP2 and MMP9 as a risk factor for idiopathic recurrent spontaneous abortions in an Indian population

Journal of Assisted Reproduction and Genetics
Deepika RamuTeena Koshy

Abstract

Matrix metalloproteinases, MMP2 and MMP9, are found to have an important role during ovulation and pregnancy because of their capacity to degrade components of the extracellular matrix (ECM) thereby facilitating cell migration and angiogenesis. In this respect, the aim of the present study was to evaluate the association of the promoter polymorphisms -1306 C > T and -1562 C/T in MMP2 and MMP9 respectively with couples diagnosed with idiopathic recurrent spontaneous abortions (IRSA). The expression levels of these two genes were also studied in fetal tissue. In this case control study, a total of 35 couples with at least three consecutive IRSA and 35 fertile couples were included. Genotype analysis was performed using polymerase chain reaction and Sanger sequencing. No statistically significant differences were found in distribution of MMP2-1306C/T and MMP9-1562C/T genotypes in the three groups between the cases and controls. Further genetic association studies on a larger number of IRSA couples, as well as evaluation of more MMP polymorphisms and their expression profiling are needed to establish the potential role of MMP polymorphisms in IRSA.

References

Apr 1, 1991·The Journal of Cell Biology·C L LibrachS J Fisher
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Oct 1, 1993·Current Opinion in Cell Biology·D E Kleiner, W G Stetler-Stevenson
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler
Jun 6, 1998·Genes & Development·H YamamotoR G Oshima
Mar 2, 1999·Reviews of Reproduction·L A Salamonsen
Jul 23, 1999·Annals of the New York Academy of Sciences·G MurphyC López-Otín
Jul 27, 1999·The Journal of Biological Chemistry·H Nagase, J F Woessner
Sep 3, 2002·Yonsei Medical Journal·Jung-Sun KimSeung-Yun Cho
Dec 5, 2002·Essays in Biochemistry·Yoshifumi Itoh, Hideaki Nagase
Jan 25, 2003·BMJ : British Medical Journal·Douglas G Altman, J Martin Bland
Feb 5, 2003·Placenta·P BischofA Campana
Jul 23, 2003·Molecular Reproduction and Development·Hee-Kyung ChoiKwang-Hyun Baek
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lei WangMichael Chopp
Mar 30, 2012·Frontiers in Genetics·Kristiina RullMaris Laan

❮ Previous
Next ❯

Citations

Jan 21, 2020·Fetal and Pediatric Pathology·Athena BehforouzHossein Neamatzadeh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.