Genetic variation in mother-child acute seroconverter pairs from Zambia.

AIDS
Federico HoffmannCharles Wood

Abstract

To characterize the envelope (Env) glycoprotein of HIV-1 in mother-infant pairs (MIP) that underwent near simultaneous or acute-phase seroconversion, we examined the Env sequence of the transmitted viruses and compare viral evolution within the pair. Three MIP from a Zambian cohort that seroconverted at the same sampling time were identified and followed longitudinally. The V1-V5 region of the HIV-1 Env gene was sequenced for each sample collected. Phylogenetic and population genetics analyses were carried out to subtype the viruses, estimate relationships among viral genotypes, and compare molecular evolution between the viral populations. Genetic analyses demonstrated a close intrapair relationship between viral sequences from each MIP. Transmission involved several closely related viral genotypes and did not result in a reduction in viral diversity. Amino acid changes were not evenly distributed along Env V1-V5 but concentrated in concordant areas within each MIP. Several positions under positive selection were shared between the MIP viruses. Interestingly, selective pressure on the virus was higher in the infants than in the mothers. In contrast to most cases of perinatal transmission of HIV-1 from chronically infected moth...Continue Reading

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Citations

Dec 4, 2012·Journal of Obstetrics and Gynaecology of India·Sudarsan SahaSumanta Kumar Mandal
Jan 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leonardo PalombiUNKNOWN DREAM Program
Feb 4, 2010·European Journal of Public Health·Jessika DeblondeMarleen Temmerman
Dec 12, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gypsyamber DʼsouzaRobert L Ferris
Jul 1, 2015·AIDS Research and Human Retroviruses·Luciane Amorim SantosLuiz Carlos Junior Alcantara
Jul 3, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Hongyan GuoXiaohong Kong
Apr 7, 2010·Critical Reviews in Clinical Laboratory Sciences·Tommy Tsan-Yuk LamJulian W Tang

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