Genetic variation in P2RX7 and pain tolerance

Pain
Oleg KamburChristopher S Nielsen

Abstract

P2X7 is a nonselective cation channel activated by extracellular ATP. P2X7 activation contributes to the proinflammatory response to injury or bacterial invasion and mediates apoptosis. Recently, P2X7 function has been linked to chronic inflammatory and neuropathic pain. P2X7 may contribute to pain modulation both by effects on peripheral tissue injury underlying clinical pain states, and through alterations in central nervous system processing, as suggested by animal models. To further test its role in pain sensitivity, we examined whether variation within the P2RX7 gene, which encodes the P2X7 receptor, was associated with experimentally induced pain in human patients. Experimental pain was assessed in Tromsø 6, a longitudinal and cross-sectional population-based study (N = 3016), and the BrePainGen cohort, consisting of patients who underwent breast cancer surgery (N = 831). For both cohorts, experimental pain intensity and tolerance were assessed with the cold-pressor test. In addition, multisite chronic pain was assessed in Tromsø 6 and pain intensity 1 week after surgery was assessed in BrePainGen. We tested whether the single-nucleotide polymorphism rs7958311, previously implicated in clinical pain, was associated with e...Continue Reading

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Citations

Nov 2, 2019·Expert Opinion on Drug Discovery·Steven L ZengMikhail Y Berezin
Jan 21, 2021·International Journal of Molecular Sciences·Dario KringelJörn Lötsch
Jan 21, 2021·The Journal of Infectious Diseases·Hui LiAndrew R Lloyd
Nov 20, 2020·Pharmacogenomics and Personalized Medicine·Cuijuan ZhengShouxiang Xie
Nov 21, 2021·Purinergic Signalling·Wen-Jing Ren, Peter Illes

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Methods Mentioned

BETA
genotyping

Software Mentioned

PLINK
R
ProbABEL
IMPUTE2
SPSS
BrePainGen
SNPTEST

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