Genetic variation in sensitivity to estrogens and breast cancer risk.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
D Joseph JerryAmy Trentham-Dietz

Abstract

Breast cancer risk is intimately intertwined with exposure to estrogens. While more than 160 breast cancer risk loci have been identified in humans, genetic interactions with estrogen exposure remain to be established. Strains of rodents exhibit striking differences in their responses to endogenous ovarian estrogens (primarily 17β-estradiol). Similar genetic variation has been observed for synthetic estrogen agonists (ethinyl estradiol) and environmental chemicals that mimic the actions of estrogens (xenoestrogens). This review of literature highlights the extent of variation in responses to estrogens among strains of rodents and compiles the genetic loci underlying pathogenic effects of excessive estrogen signaling. Genetic linkage studies have identified a total of the 35 quantitative trait loci (QTL) affecting responses to 17β-estradiol or diethylstilbestrol in five different tissues. However, the QTL appear to act in a tissue-specific manner with 9 QTL affecting the incidence or latency of mammary tumors induced by 17β-estradiol or diethylstilbestrol. Mammary gland development during puberty is also exquisitely sensitive to the actions of endogenous estrogens. Analysis of mammary ductal growth and branching in 43 strains of...Continue Reading

References

Oct 1, 1977·Journal of Toxicology and Environmental Health·D L GreenmanC R Breeden
Jan 1, 1987·Journal of Chronic Diseases·M C Pike
Jan 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D L Wendell, J Gorski
Jul 29, 1998·International Journal of Cancer. Journal International Du Cancer·T LifstedK W Hunter
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·R C GuzmanS Nandi
Feb 16, 2000·The Journal of Investigative Dermatology. Symposium Proceedings·R C SmartC L Robinette
Mar 8, 2000·Environmental Health Perspectives·X LongR M Bigsby
Feb 7, 2001·American Journal of Epidemiology·W C ChieB MacMahon
Sep 26, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D L WendellJ Gorski
Sep 26, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T Le VoyerK Hunter
Feb 13, 2001·Molecular and Cellular Endocrinology·K A GouldJ Gorski
May 2, 2001·Human Reproduction·J L Spearow, M Barkley
Aug 2, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J L SpearowM Barkley
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·L RajkumarS Nandi
Aug 6, 2002·Journal of Mammary Gland Biology and Neoplasia·Leslie Bernstein
Dec 4, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Douglas L WendellParker Kelley
May 29, 2004·Carcinogenesis·Jyotsna PandeyDouglas L Wendell
Nov 15, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karen A GouldJames D Shull
Nov 15, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jyotsna PandeyDouglas L Wendell
May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karen A GouldJames D Shull
Oct 5, 2006·Journal of the National Cancer Institute·A Heather EliassenSusan E Hankinson
Jan 30, 2007·Breast Cancer Research : BCR·Lakshmanaswamy RajkumarDaniel Medina
Apr 24, 2007·Environmental Health Perspectives·Perinaaz R WadiaAna M Soto
Sep 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yuxin FengSohaib A Khan
Sep 19, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·James D ShullKaren A Gould
Mar 20, 2008·Annual Review of Public Health·Ross L Prentice, Garnet L Anderson

❮ Previous
Next ❯

Citations

Feb 21, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ivan RusynKaren L Svenson
Mar 11, 2020·Journal of Mammary Gland Biology and Neoplasia·Karen A DunphyD Joseph Jerry
Mar 25, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·A GossetF Trémollieres

❮ Previous
Next ❯

Methods Mentioned

BETA
ChIP-seq

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Eunjung LeeGiske Ursin
Environmental and Molecular Mutagenesis
L Michelle Bennett, Barbara J Davis
European Journal of Obstetrics, Gynecology, and Reproductive Biology
C H van Gils
© 2022 Meta ULC. All rights reserved