Genetic variation in the CLOCK gene is associated with idiopathic recurrent spontaneous abortion

PloS One
Alenka HodžićBorut Peterlin

Abstract

Physiological studies in animals and human support an important role of circadian system in reproduction. The aim of this study was to investigate the potential association of CLOCK gene polymorphisms with idiopathic recurrent spontaneous abortion (IRSA). We performed a case-control study. The study group consisted of 268 women with a history of three or more idiopathic recurrent spontaneous abortions and 284 women with at least two live births and no history of pathologic pregnancies all from Slovenia and Serbia. Two SNPs in the CLOCK gene were chosen and genotyped. The results showed a statistically significant difference in genotype distribution between the two groups in the CLOCK gene for rs6850524 and rs11932595. Our analysis showed that G allele under dominant model (GG+GC/CC) for rs6850524 (p = 2∙10-4, OR = 2.28, 95%CI = 1.46-3.56) as well as G allele under dominant model (GA+AA/AA) for rs11932595 (p = 0.04, OR = 1.47, 95%CI = 1.01-2.04) might be risk factors against IRSA. Our data suggest that genetic variability in the CLOCK gene is associated with IRSA warranting further confirmation and mechanistic investigations.

References

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Citations

May 15, 2019·Current Opinion in Obstetrics & Gynecology·Sydney Kaye WillisLauren Anne Wise
Oct 24, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Jacqueline Mills, Wendy Kuohung
Feb 6, 2020·International Journal of Molecular Sciences·Xiaoyue PanSamantha Mota
Sep 28, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Linden Jane StockerYing Chin Cheong

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Methods Mentioned

BETA
RSA
FRET
Genotyping

Software Mentioned

R
Haploview
SDS

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