Genetic variation in the human cytochrome P450 supergene family

Pharmacogenetics and Genomics
Kohei FujikuraVolker M Lauschke

Abstract

Single nucleotide variations (SNVs) in the cytochrome P450 (CYP) gene family are a primary cause of interindividual differences in therapeutic effects and adverse reactions to drugs. However, we still lack important information on the extent of CYP polymorphisms at the population level. Here, we developed a comprehensive data set of SNVs in all 57 human CYP genes by integrating data from two extensive population sequencing projects and analyzed the distribution of SNVs in different subpopulations. CYP genetic variants derived from the NHLBI and 1000 Genomes project were classified by variant type, frequency, and ethnic origins. The genetic variability of CYP genes was normalized on the basis of nonlinear regression and the total number of genetic variations was estimated by the derived formulas. In total, we detected 6165 SNVs, of which many were novel. The vast majority (83.2%) of all SNVs in coding regions were very rare (minor allele frequency <0.1%). On the basis of the regression analysis, the total number of genetic variations in human CYP genes was calculated to be 3.4 × 10 and 4.8 × 10 for a population size of one million in Europeans and Africans, respectively. Our results suggest that the variant spectrum of human CYP...Continue Reading

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Citations

Dec 26, 2015·Trends in Pharmacological Sciences·Volker M Lauschke, Magnus Ingelman-Sundberg
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Methods Mentioned

BETA
genotyping
exome sequencing
PCA

Software Mentioned

Python
AF Calculator
GeneCards
Variant Tools
SIFT
Excel
R
PolyPhen

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