Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
K KingC G Mathew

Abstract

The immunoglobulin superfamily 6 gene (IGSF6) on chromosome 16p11-p12 has been investigated as a positional and functional candidate for inflammatory bowel disease (IBD) susceptibility. Screening of the six exons of IGSF6 for single nucleotide polymorphisms (SNPs) detected four novel SNPs, and validated three of six SNPs listed in the international SNP database (dbSNP). The seven SNPs in IGSF6 formed five distinct linkage disequilibrium groups. There was no evidence for association of the common SNPs with disease in a large cohort of patients with IBD. The novel SNPs and the linkage disequilibrium map will be a useful resource for the analysis of IGSF6 in other immune disorders.

References

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Citations

Oct 24, 2012·Journal of Gastroenterology·Fumiaki UenoUNKNOWN Guidelines Project Group of the Research Group of Intractable Inflammatory Bowel Disease subsidized by the Ministry of Healt
Jul 14, 2006·Colloids and Surfaces. B, Biointerfaces·Kun-Xian ShuBiao Li
Oct 16, 2018·Molecular Medicine Reports·Wendong WangXiaotong Chang
Oct 8, 2020·Animals : an Open Access Journal From MDPI·Hongyang WangYongsong Tan

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