Genetic variation in the inhibin pathway and risk of testicular germ cell tumors.

Cancer Research
Mark P PurdueKatherine A McGlynn

Abstract

Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors. It is not known whether genetic variation in the inhibin pathway also influences susceptibility to testicular germ cell tumors (TGCT), the most common testicular cancer in young men. To address this question, we conducted a case-control analysis (577 cases; 707 controls) of single-nucleotide polymorphisms (SNP) in genes in the inhibin pathway among participants in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study. Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped. Odds ratios (OR) and 95% confidence intervals (CI) relating variant genotypes to TGCT risk were calculated using unconditional logistic regression. Among White subjects, an elevated risk of TGCT was observed for carriers of the T allele of the INHA variant rs2059693 (CT genotype: OR, 1.33; 95% CI, 1.04-1.71; TT: OR, 1.60; 95% CI, 1.01-2.52; P(trend) = 0.008). The association with rs2059693 was stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; CT: OR, 1.63; 95% CI, 0.8...Continue Reading

References

Jul 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·P P Nylander
Nov 1, 1995·Cancer Causes & Control : CCC·M M BraunR N Hoover
Mar 20, 1998·The Journal of Clinical Endocrinology and Metabolism·S L MellorG P Risbridger
Dec 1, 2000·Human Reproduction·A N ShellingI M Winship
Nov 27, 2001·European Journal of Endocrinology·L CobellisF Petraglia
Jan 31, 2002·Molecular Endocrinology·Jacqueline F SchmittGail P Risbridger
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Dec 19, 2003·American Journal of Human Genetics·Christopher S CarlsonDeborah A Nickerson
Aug 21, 2004·Seminars in Reproductive Medicine·Anne E O'Connor, David M De Kretser
Sep 29, 2004·Molecular and Cellular Endocrinology·G P RisbridgerD M Peehl
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Feb 10, 2006·Annals of the New York Academy of Sciences·K L LovelandD A Jans
Nov 7, 2006·Fertility and Sterility·Ashwini L ChandCraig A Harrison
Nov 18, 2006·American Journal of Epidemiology·Katherine A McGlynnRalph L Erickson
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mark P PurdueKatherine A McGlynn

❮ Previous
Next ❯

Citations

Nov 26, 2010·World Journal of Gastroenterology : WJG·Dong-Mei WuZheng-Dong Zhang
Sep 3, 2014·Molecular Human Reproduction·Francesco Elia MarinoElspeth Gold
Aug 11, 2011·Molecular and Cellular Endocrinology·Andrew N Shelling
May 17, 2011·Hematology/oncology Clinics of North America·Andreas Stang, Oliver Kuss
Jul 22, 2010·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·X ZhaoM F Rothschild
Jul 30, 2014·Seminars in Cancer Biology·Martin A Rijlaarsdam, Leendert H J Looijenga
Dec 19, 2017·Frontiers in Endocrinology·Kate L LovelandHans-Christian Schuppe
Oct 31, 2009·World Journal of Hepatology·Emanuel KreidlMichael Grusch
Apr 1, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Omid BeikiTahereh Moradi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cytokine & Growth Factor Reviews
E M A BallG P Risbridger
Molecular and Cellular Endocrinology
Kristina B LundinYvonne Lundberg Giwercman
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Åke VästermarkAleksander Giwercman
© 2022 Meta ULC. All rights reserved