Genetic variation in the myeloperoxidase gene and cognitive impairment in multiple sclerosis

Journal of Negative Results in Biomedicine
I MannaA Quattrone

Abstract

There is evidence that multiple sclerosis (MS) may associated with cognitive impairment in 25 to 40% of cases. The gene encoding myeloperoxidase (MPO) is involved in molecular pathways leading to beta-amyloid deposition. We investigated a functional biallelic (G/A) polymorphism in the promoter region (-463) of the MPO gene in 465 patients affected by MS, divided into 204 cognitively normal and 261 impaired. We did not find significant differences in allele or genotype distributions between impaired and preserved MS patients. Our findings suggest that MPO polymorphism is not a risk factor for cognitive impairment in MS.

References

Sep 19, 1997·Mayo Clinic Proceedings·W E HogancampB G Weinshenker
Oct 23, 1997·Journal of Neuroimmunology·R M NagraW F Reynolds
Apr 1, 2000·Journal of Neuroimmunology·O H KantarciB G Weinshenker
Mar 17, 2004·Archives of Neurology·Mario ZappiaAldo Quattrone
Jun 30, 2004·Multiple Sclerosis : Clinical and Laboratory Research·B Zakrzewska-PniewskaH Kwiecinski

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Citations

Jan 25, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Monika TalarowskaPiotr Gałecki
Oct 1, 2010·Acta Neuropsychiatrica·Piotr GałeckiJanusz Szemraj

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Methods Mentioned

BETA
transfection

Software Mentioned

Statistical Package for Social Sciences software SPSS

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