Genetic variation in the pro-melanin-concentrating hormone gene affects carcass traits in Bos taurus cattle

Animal Genetics
S C Helgeson, Sheila M Schmutz

Abstract

Mammalian pro-melanin-concentrating hormone (PMCH) has previously been shown to affect feed intake in rodent species. The objectives of this study were to sequence the Bos taurus PMCH gene in order to identify any existing genetic variants and to evaluate whether these affected carcass traits. An A-to-T SNP was identified at position -134 relative to the ATG start codon (g.-134A>T). The alleles at this SNP were significantly associated with average fat and grade fat in two crossbred populations of Bos taurus cattle. The g.-134T allele may introduce a binding site for the transcriptional repressor, adenovirus E4 promoter binding protein, which may contribute to this effect. The g.-134A allele occurred in 67% of cattle examined and was associated with higher fat levels.

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Citations

Sep 26, 2012·Nutritional Neuroscience·Ewa K StachowiakMulchand S Patel
May 22, 2008·Animal Genetics·J CañónS Dunner
Feb 26, 2010·The International Journal of Clinical and Experimental Hypnosis·Donald L Nathanson
Nov 19, 2013·Journal of Animal Science·L J WalterT E Lawrence
Apr 11, 2019·Frontiers in Genetics·Pâmela A AlexandreHeidge Fukumasu
Jun 10, 2021·Tropical Animal Health and Production·Norberto Ismael Angulo-ValenzuelaPablo Luna-Nevárez

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