Genetic variation in transmission success of the Lyme borreliosis pathogen Borrelia afzelii

Ticks and Tick-borne Diseases
Nicolas TonettiL Gern

Abstract

The vector-to-host and host-to-vector transmission steps are the two critical events that define the life cycle of any vector-borne pathogen. We expect negative genetic correlations between these two transmission phenotypes, if parasite genotypes specialized at invading the vector are less effective at infecting the vertebrate host and vice versa. We used the tick-borne bacterium Borrelia afzelii, a causative agent of Lyme borreliosis in Europe, to test whether genetic trade-offs exist between tick-to-host, systemic (host-to-tick), and a third mode of co-feeding (tick-to-tick) transmission. We worked with six strains of B. afzelii that were differentiated according to their ospC gene. We compared the three components of transmission among the B. afzelii strains using laboratory rodents as the vertebrate host and a laboratory colony of Ixodes ricinus as the tick vector. We used next generation matrix models to combine these transmission components into a single estimate of the reproductive number (R0) for each B. afzelii strain. We also tested whether these strain-specific estimates of R0 were correlated with the strain-specific frequencies in the field. We found significant genetic variation in the three transmission components...Continue Reading

References

Nov 1, 1996·Experimental & Applied Acarology·L GernJ Moret
Nov 20, 1998·Science·D Ebert
Sep 10, 1999·International Journal for Parasitology·S K Wikel
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J OhnishiA M de Silva
Jul 4, 2001·Trends in Microbiology·D E Dykhuizen, G Baranton
Dec 25, 2002·Emerging Infectious Diseases·Dania RichterFranz-Rainer Matuschka
Mar 26, 2003·Vector Borne and Zoonotic Diseases·N S ZeidnerJ Piesman
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dorothee GrimmPatricia A Rosa
Dec 1, 1996·Parasitology Today·S E RandolphP A Nuttall
Sep 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wei-Gang QiuBenjamin J Luft
Oct 30, 2004·Genetics·Dustin Brisson, Daniel E Dykhuizen
Nov 6, 2004·Applied and Environmental Microbiology·Markéta DerdákováDurland Fish
May 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jacobus C de RoodeAndrew F Read
Jun 9, 2005·Parasitology·J Piesman, L Gern
Apr 6, 2006·International Journal of Systematic and Evolutionary Microbiology·Dania RichterGuy Baranton
Feb 3, 2007·International Journal of Medical Microbiology : IJMM·Volker FingerleUlrike Schulte-Spechtel
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christophe FraserWilliam P Hanage
Nov 6, 2007·Applied and Environmental Microbiology·Klára HanincováKlaus Kurtenbach
Apr 11, 2008·Molecular Microbiology·Justin D Radolf, Melissa J Caimano
May 3, 2008·Infectious Disease Clinics of North America·Kit TillyPhilip E Stewart
May 9, 2008·The American Naturalist·N A HarteminkJ A P Heesterbeek
Sep 11, 2008·The Journal of Infectious Diseases·Gary P WormserIra Schwartz
Oct 23, 2010·Journal of Evolutionary Biology·O HellgrenL Råberg
Apr 28, 2012·Journal of Evolutionary Biology·L Råberg

❮ Previous
Next ❯

Citations

Sep 20, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Maxime JacquetMaarten J Voordouw
Dec 3, 2015·Environmental Microbiology·Dieter HeylenHein Sprong
Sep 29, 2015·Environmental Microbiology·Maxime JacquetMaarten J Voordouw
May 28, 2016·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Adam NorekAlena Žákovská
Jan 6, 2017·Scientific Reports·Dieter J A HeylenMaarten J Voordouw
Nov 12, 2016·Applied and Environmental Microbiology·Jonas DurandMaarten J Voordouw
Jan 23, 2019·Molecular Microbiology·Danielle M TuftsYi-Pin Lin
Sep 22, 2019·Applied and Environmental Microbiology·Andrea Gomez-ChamorroMaarten J Voordouw
May 2, 2019·Scientific Reports·Andrea Gomez-ChamorroMaarten Jeroen Voordouw
Jul 12, 2017·Scientific Reports·Alessandro BelliMaarten J Voordouw
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Dolores GennéMaarten J Voordouw

❮ Previous
Next ❯

Related Concepts