Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone.

PloS One
Kathrine LundeHiroaki Matsunami

Abstract

Although odour perception impacts food preferences, the effect of genotypic variation of odorant receptors (ORs) on the sensory perception of food is unclear. Human OR7D4 responds to androstenone, and genotypic variation in OR7D4 predicts variation in the perception of androstenone. Since androstenone is naturally present in meat derived from male pigs, we asked whether OR7D4 genotype correlates with either the ability to detect androstenone or the evaluation of cooked pork tainted with varying levels of androstenone within the naturally-occurring range. Consistent with previous findings, subjects with two copies of the functional OR7D4 RT variant were more sensitive to androstenone than subjects carrying a non-functional OR7D4 WM variant. When pork containing varying levels of androstenone was cooked and tested by sniffing and tasting, subjects with two copies of the RT variant tended to rate the androstenone-containing meat as less favourable than subjects carrying the WM variant. Our data is consistent with the idea that OR7D4 genotype predicts the sensory perception of meat containing androstenone and that genetic variation in an odorant receptor can alter food preferences.

References

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Citations

Jun 5, 2014·BMC Genomics·Suzanne J RoweAlan L Archibald
Apr 16, 2014·The Journal of General Physiology·Zita PeterlinMatthew E Rogers
Oct 11, 2012·BMC Neuroscience·Andreas KellerLeslie B Vosshall
Jul 24, 2013·Food Quality and Preference·John E HayesAlissa L Allen
Feb 5, 2016·Meat Science·B MartínezM D Garrido
Dec 22, 2015·Chemical Senses·Carla S Silva TeixeiraAntónio C Silva Ferreira
Feb 11, 2015·Current Opinion in Neurobiology·Yue Jiang, Hiroaki Matsunami
Aug 12, 2014·Biochemical Society Transactions·Darren W Logan
May 7, 2015·Genes & Nutrition·Edwin C M MarimanPing Wang
Feb 21, 2018·Angewandte Chemie·Claire A de MarchJérôme Golebiowski
Dec 7, 2018·Nature Reviews. Drug Discovery·Sung-Joon LeeHanns Hatt
Nov 2, 2019·Animals : an Open Access Journal From MDPI·Michel Bonneau, Ulrike Weiler
Aug 10, 2016·BMC Neuroscience·Andreas Keller, Leslie B Vosshall
Feb 20, 2021·Critical Reviews in Food Science and Nutrition·Rifat Nowshin RakaJianming Jin
Aug 20, 2021·British Journal of Pharmacology·Siyu ZhangHanbing Li

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Methods Mentioned

BETA
NMR
PCR

Software Mentioned

JMP

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