Genetic variation of major histocompatibility complex (MHC) in wild Red Junglefowl (Gallus gallus)

Poultry Science
Hoa Nguyen-PhucMark E Berres

Abstract

The major histocompatibility complex (MHC) is a multi-family gene cluster that encodes proteins with immuno-responsive function. While studies of MHC in domesticated poultry are relatively common, very little is known about this highly polymorphic locus in wild Red Junglefowl (Gallus gallus), the natural progenitor of domestic chickens. We investigated the diversity of MHC within and among four wild Red Junglefowl populations across diversified natural habitats in South Central Vietnam. Based on a SNP panel of 84 sites spanning 210 Kb of the MHC-B locus, we identified 310 unique haplotypes in 398 chromosomes. None of these haplotypes have been described before and we did not observe any of the wild Red Junglefowl haplotypes in domesticated chickens. Analysis of molecular variance (AMOVA) revealed that 94.51% of observed haplotype variation was accounted for at the within individual level. Little genetic variance was apportioned within and among populations, the latter accounting only for 0.83%. We also found evidence of increased recombination, including numerous hotspots, and limited linkage disequilibrium among the 84 SNP sites. Compared to an average haplotype diversity of 3.55% among seventeen lines of domestic chickens, ou...Continue Reading

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Citations

Aug 4, 2019·Poultry Science·Gabriela M IglesiasJanet E Fulton
Sep 30, 2020·Poultry Science·Prabuddha ManjulaJun Heon Lee
Mar 20, 2021·Vavilovskiĭ Zhurnal Genetiki I Selekt︠s︡ii·А М BorodinV I Fisinin
Sep 7, 2021·Frontiers in Genetics·Yiming YuanLing Lian
Apr 30, 2017·Poultry Science·J E FultonM Honkatukia

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