PMID: 9524073Apr 2, 1998Paper

Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity

Biological Chemistry
J Mikolajczyk-PawlinskaJan Potempa

Abstract

Porphyromonas gingivalis hemagglutinating cysteine proteinases (gingipains) are considered as important virulence factors in the development of adult periodontitis. Using Southern blot analysis it was determined that genes of three distinct but related gingipains (gingipain-R1, gingipain-R2 and gingipain-K) were present in all tested strains including HG66, ATCC 33277, W50, E-20-1, EM-3, 381, A7436, and IKG5, with a region encoding a part of the hemagglutinin domain of gingipain-R1 and gingipain-K showing considerable variability. In contrast, the loci encoding gingipain-R1 (rgp1) and gingipain-R2 (rgp2) were strongly conserved excluding the concurrent occurrence of other gingipain-R-like genes such as cpgR and agp. Significantly, no evidence could be found to support the expression of a gene coding for the putative proteinase porphypain, an enzyme suggested to have both gingipain-R and gingipain-K activity.

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Citations

Jun 14, 2013·PloS One·N Laila HuqEric C Reynolds
Sep 5, 2012·Biological Chemistry·Maryta SztukowskaJan Potempa
Feb 21, 2003·Journal of Periodontology·Takahisa Imamura
May 7, 2009·Future Microbiology·Rebecca E FitzpatrickRobert N Pike
Jan 3, 2013·Molecular Oral Microbiology·E FröhlichS Eick
Dec 19, 2009·Periodontology 2000·Rishi D PathiranaEric C Reynolds
Jan 18, 2005·FEMS Microbiology Reviews·Teresa OlczakCaroline Attardo Genco
Mar 1, 2011·European Journal of Microbiology & Immunology·N Li, C A Collyer
Aug 11, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M A CurtisM Rangarajan
May 31, 2014·Journal of Dental Research·C K MantriH Xie
Apr 28, 2005·Journal of Periodontal Research·T BeiklerT F Flemmig
Apr 10, 2010·Microbiology·Devon O OsbourneHansel M Fletcher
Mar 4, 2000·Journal of Periodontal Research·M A CurtisJ Aduse-Opoku
Jan 21, 2003·The Journal of Biological Chemistry·Jowita MikolajczykGuy S Salvesen
Sep 21, 2019·Scientific Reports·Yasumitsu SakamotoNobutada Tanaka
Aug 12, 1999·Biochemical and Biophysical Research Communications·A BanbulaJ Potempa
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·R J Lamont, H F Jenkinson

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