Genetic Variation of the Vitamin D Binding Protein Affects Vitamin D Status and Response to Supplementation in Infants

The Journal of Clinical Endocrinology and Metabolism
Maria Enlund-CerulloMinna Pekkinen

Abstract

Single nucleotide polymorphisms (SNPs) of the vitamin D binding protein encoding the GC (group component) gene affect 25-hydroxyvitamin D (25OHD) concentrations, but their influence on vitamin D status and response to vitamin D supplementation in infants is unknown. To study GC genotype-related differences in 25OHD concentrations and the response to supplementation during a vitamin D intervention study in infants. In this randomized controlled trial, healthy term infants received vitamin D3 (10 or 30 μg/d) from 2 weeks to 24 months of age. GC SNPs rs2282679, rs4588, rs7041, and rs1155563 were genotyped. rs4588/7041 diplotype and haplotypes of rs2282679, rs4588, and rs7041 (Haplo3SNP) and of all four SNPs (Haplo4SNP) were determined. 25OHD measured in cord blood at birth and at 12 and 24 months during intervention. A total of 913 infants were included. Minor allele homozygosity of all studied GC SNPs, their combined haplotypes, and rs4588/rs7041 diplotype 2/2 were associated with lower 25OHD concentrations at all time points in one or both intervention groups [analysis of covariance (ANCOVA) P < 0.043], with the exception of rs7041, which did not affect 25OHD at birth. In the high-dose supplementation group receiving 30 μg/d vit...Continue Reading

Associated Clinical Trials

Nov 8, 2012·Sture Andersson

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Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Jeffrey D Roizen, Michael A Levine
May 21, 2020·The American Journal of Clinical Nutrition·Karen M O'Callaghan, Daniel E Roth
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Sep 21, 2021·The Journal of Clinical Endocrinology and Metabolism·Cora M BestAndrew N Hoofnagle

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