Genetic variations altering FSH action affect circulating hormone levels as well as follicle growth in healthy peripubertal girls

Human Reproduction
Alexander S BuschAnders Juul

Abstract

Do variants of the genes encoding follicle stimulating hormone (FSH) beta subunit (B) and FSH receptor (R) impact circulating reproductive hormone levels and ovarian follicle maturation in healthy peripubertal girls? FSHB and FSHR genetic variants exert, alone or their combination, distinct effects on reproductive hormone levels as well as ovarian follicle maturation in healthy peripubertal girls. FSHB and FSHR genetic variants impact reproductive hormone levels as well as associated pathologies in women. While FSHR c. 2039A>G is known to alter gonadotrophin levels in women, FSHR c.-29G>A has not yet been shown to exert effect and there are conflicting results concerning FSHB c.-211G>T. This population-based study included 633 girls recruited as part of two cohorts, the COPENHAGEN Puberty Study (2006-2014, a cross-sectional and ongoing longitudinal study) and the Copenhagen Mother-Child Cohort (1997-2002, including transabdominal ultrasound (TAUS) of the ovaries in a subset of 91 peripubertal girls). Clinical examinations, including pubertal breast stage (Tanner's classification B1-B5) were performed. Circulating levels of FSH, luteinizing hormone (LH), estradiol, anti-Mullerian hormone (AMH) and inhibin-B were assessed by immu...Continue Reading

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Citations

Aug 16, 2016·International Journal of Cardiology·Jie V Zhao, C Mary Schooling
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Alexander S BuschAnders Juul
Oct 28, 2017·The Journal of Clinical Endocrinology and Metabolism·Alexander S BuschAnders Juul
Dec 24, 2016·The Journal of Clinical Endocrinology and Metabolism·Marie Lindhardt JohansenAnders Juul
Sep 22, 2020·World Journal of Stem Cells·Khadijeh BahrehbarHossein Baharvand
Dec 1, 2020·The FEBS Journal·Antara A BanerjeeSmita D Mahale
Aug 6, 2021·International Journal of General Medicine·Xue WangQing-Chun Li

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