Genetic variations for egg quality of chickens at late laying period revealed by genome-wide association study

Scientific Reports
Zhuang LiuNing Yang

Abstract

With the extension of the egg-laying cycle, the rapid decline in egg quality at late laying period has aroused great concern in the poultry industry. Herein, we performed a genome-wide association study (GWAS) to identify genomic variations associated with egg quality, employing chicken 600 K high-density SNP arrays in a population of 1078 hens at 72 and 80 weeks of age. The results indicated that a genomic region spanning from 8.95 to 9.31 Mb (~0.36 Mb) on GGA13 was significantly associated with the albumen height (AH) and the haugh unit (HU), and the two most significant SNPs accounted for 3.12 ~ 5.75% of the phenotypic variance. Two promising genes, MSX2 and DRD1, were mapped to the narrow significant region, which was involved in embryonic and ovary development and found to be related to egg production, respectively. Moreover, three interesting genes, RHOA, SDF4 and TNFRSF4, identified from three significant loci, were considered to be candidate genes for egg shell colour. Findings in our study could provide worthy theoretical basis and technological support to improve late-stage egg quality for breeders.

References

Aug 1, 1988·The Journal of Endocrinology·P J SharpH C Pedersen
Apr 1, 1995·General and Comparative Endocrinology·O M YoungrenM E el Halawani
Feb 1, 1994·Current Opinion in Genetics & Development·C Nobes, A Hall
Apr 21, 2001·Biometrics·B Devlin, K Roeder
Mar 27, 2002·Neuroendocrinology·Orlan YoungrenMohamed El Halawani
Aug 7, 2002·Poultry Science·M Tuiskula-HaavistoA Mäki-Tanila
Aug 14, 2003·Journal of Molecular Endocrinology·A Al KahtaneM El Halawani
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Feb 10, 2009·American Journal of Human Genetics·Brian L Browning, Sharon R Browning
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
May 5, 2010·Experimental & Molecular Medicine·Hye-Lim LeeJeong-Hwa Baek
Nov 9, 2010·Animal Genetics·M Tuiskula-HaavistoJ Vilkki
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Apr 26, 2011·Biochemical and Biophysical Research Communications·Abdul S QadirJeong-Hwa Baek
Jun 2, 2011·BMC Genomics·Martien A M GroenenHans H Cheng
Jan 28, 2012·Biochemical and Biophysical Research Communications·Min Jung KimJong Kyung Sonn
Jun 19, 2012·Nature Genetics·Xiang Zhou, Matthew Stephens
Jan 30, 2013·BMC Genomics·Andreas KranisDavid W Burt
Mar 19, 2014·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·A WolcJ C M Dekkers
Oct 21, 2015·Genetics, Selection, Evolution : GSE·Hélène RoméPascale Le Roy
Nov 26, 2015·Nucleic Acids Research·Zhi-Liang HuJames M Reecy
May 20, 2016·International Journal of Biological Sciences·Judong LuoJianming Chen

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Citations

Apr 21, 2020·British Poultry Science·Yanli DuChangrong Ge

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Methods Mentioned

BETA
chip
PCR
GTPase
GTPases
blood sample
genotyping

Software Mentioned

Axiom Genotyping
GCTA
GEMMA
Ensembl
Haploview
Variant Effect Predictor ( VEP )
simpleM package
Affymetrix Power Tools
PLINK
DMU

Related Concepts