Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus

Annals of Surgery
G LurjeHeinz-Josef Lenz

Abstract

The aim of this study was to determine whether the risk of systemic disease after esophagectomy could be predicted by angiogenesis-related gene polymorphisms. Systemic tumor recurrence after curative resection continues to impose a significant problem in the management of patients with localized esophageal adenocarcinoma (EA). The identification of molecular markers of prognosis will help to better define tumor stage, indicate disease progression, identify novel therapeutic targets, and monitor response to therapy. Proteinase-activated-receptor 1 (PAR-1) and epidermal growth factor (EGF) have been shown to mediate the regulation of local and early-onset angiogenesis, and in turn may impact the process of tumor growth and disease progression. We investigated tissue samples from 239 patients with localized EA treated with surgery alone. DNA was isolated from formalin-fixed paraffin-embedded normal esophageal tissue samples and polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism and 5'-end [gamma-P] ATP-labeled polymerase chain reaction methods. PAR-1 -506 ins/del (adjusted P value=0.011) and EGF +61 A>G (adjusted P value=0.035) showed to be adverse prognostic markers, in both univa...Continue Reading

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Citations

Jan 8, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F G UzunogluY K Vashist
Jun 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Siwen Hu-LieskovanHeinz-Josef Lenz
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Jun 27, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lawson EngGeoffrey Liu

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