Genetic variations in ARE1 mediate grain yield by modulating nitrogen utilization in rice

Nature Communications
Qing WangJianru Zuo

Abstract

In crops, nitrogen directly determines productivity and biomass. However, the improvement of nitrogen utilization efficiency (NUE) is still a major challenge in modern agriculture. Here, we report the characterization of are1, a genetic suppressor of a rice fd-gogat mutant defective in nitrogen assimilation. ARE1 is a highly conserved gene, encoding a chloroplast-localized protein. Loss-of-function mutations in ARE1 cause delayed senescence and result in 10-20% grain yield increases, hence enhance NUE under nitrogen-limiting conditions. Analysis of a panel of 2155 rice varieties reveals that 18% indica and 48% aus accessions carry small insertions in the ARE1 promoter, which result in a reduction in ARE1 expression and an increase in grain yield under nitrogen-limiting conditions. We propose that ARE1 is a key mediator of NUE and represents a promising target for breeding high-yield cultivars under nitrogen-limiting condition.

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Citations

Jan 11, 2020·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhihua ZhangChengcai Chu
Aug 6, 2020·Scientific Reports·Lunjing DuJichao Yuan
Nov 30, 2019·Frontiers in Plant Science·Vívian Ebeling VianaAntonio Costa de Oliveira
Aug 11, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Meng GuoJianru Zuo
Dec 24, 2020·Journal of Agricultural and Food Chemistry·Yinpei LiangHongwei Chen
Aug 28, 2021·International Journal of Molecular Sciences·Mengmeng HouJingguang Chen
Oct 16, 2021·Physiologia Plantarum·Pratibha GourSaurabh Raghuvanshi

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Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

TMHMM
MEGA
TargetP

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