Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer

BioMed Research International
Xin CuiJian-Jun Xu

Abstract

Prostate cancer is a common cancer in men. Genetic variations in inflammatory response genes can potentially influence the risk of prostate cancer. We aimed to examine the association between PPARG Pro12Ala, NFKB1 -94 ins/del, NFKBIA -826C/T, COX-1 (50C>T), and COX-2 (-1195G>A) polymorphisms on prostate cancer risk. The genotypes of the polymorphisms were ascertained in 543 prostate cancer patients and 753 controls through PCR-RFLP and the risk association was evaluated statistically using logistic regression analysis. The NFKB1 -94 polymorphism was shown to decrease prostate cancer risk in both heterozygous and homozygous comparison models (odds ratios of 0.74 (95% CI = 0.58-0.96) (P = 0.02) and 0.57 (95% CI = 0.42-0.78) (P < 0.01), resp.). An opposite finding was observed for COX-2 (-1195) polymorphism (odds ratios of 1.58 (95% CI = 1.15-2.18) (P < 0.01) for heterozygous comparison model and 2.08 (95% CI = 1.48-2.92) (P < 0.01) for homozygous comparison model). No association was observed for other polymorphisms. In conclusion, NFKB1 -94 ins/del and COX-2 (-1195G>A) polymorphisms may be, respectively, associated with decreased and increased prostate cancer risk in the Chinese population.

References

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Citations

Apr 22, 2017·Endocrine-related Cancer·Theo S PlantingaCarmen E Georgescu
May 3, 2019·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Hassan R Dhaini, Zeina Daher
Mar 12, 2020·Current Drug Metabolism·Jyothsna KancharlaAfroz Alam
Nov 7, 2020·International Journal of Environmental Research and Public Health·Ariane MbemiPaul B Tchounwou

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

SPSS

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