Genetic variations in interleukin-6 polymorphism and the association with susceptibility and overall survival of osteosarcoma

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yunlong QiMidori Tada

Abstract

Interleukin-6 (IL-6), a central proinflammatory cytokine, may be involved in both development and progression of many human malignancies. Therefore, we aimed to evaluate any associations of IL-6 gene polymorphisms with susceptibility and overall survival of osteosarcoma in a Chinese population. A total of 412 subjects, including 206 patients with osteosarcoma and 206 healthy controls, were recruited and were assessed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in this study. Significant differences of genotype distribution were observed between osteosarcoma cases and controls at the IL-6 -174 G/C genotypes. Compared with the homozygote GG, the heterozygous GC genotype was associated with significantly increased risk for osteosarcoma (odds ratio [OR] = 1.58, 95 % confidence interval [CI] = 1.13-3.05, p = 0.028); the CC genotype was associated with increased risk for osteosarcoma (OR = 1.57, 95 % CI = 1.21-3.26, p = 0.022). Moreover, the genotype CC of IL-6 -174 G/C carried a higher risk of osteosarcoma metastasis and later Enneking stages, compared with the GG genotype. The IL-6 -174 G/C genotype was associated with risk for development and metastasis of osteosarcoma in Chinese Han population.

References

Dec 11, 1996·International Journal of Cancer. Journal International Du Cancer·E Kramárová, C A Stiller
Jul 22, 2004·The Oncologist·Neyssa MarinaRichard Gorlick
Apr 20, 2005·Journal of Cellular Biochemistry·Zoran CuligAlfred Hobisch
Jul 13, 2006·Expert Review of Anticancer Therapy·Alexander J Chou, Richard Gorlick
Dec 21, 2006·The International Journal of Biological Markers·E VairaktarisE Patsouris
May 27, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Rohit UpadhyayBalraj Mittal
Mar 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tasnim Ara, Yves A Declerck
Feb 22, 2012·Cancer Research·Kevin B JonesRami I Aqeilan
May 17, 2012·BMC Veterinary Research·Ilse BoermanJolle Kirpensteijn
Apr 27, 2013·Lancet·Emma J CrosbieHenry C Kitchener
May 16, 2013·World Journal of Gastroenterology : WJG·Lydia GiannitrapaniGiuseppe Montalto
Jul 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Sheng-Bin BaiJin-Jie Zhong
Jan 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mónica GomesRui Medeiros

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yang ChenJinmin Ding
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Jing LiMin Pan
The International Journal of Periodontics & Restorative Dentistry
Liu JingjinWang Yonggong
© 2021 Meta ULC. All rights reserved